Document Detail


Role of hepatic vein catheterisation and transient elastography in the diagnosis of idiopathic portal hypertension.
MedLine Citation:
PMID:  22721839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Idiopathic portal hypertension is a rare cause of portal hypertension, frequently misdiagnosed as cryptogenic cirrhosis. This study evaluates specific findings at hepatic vein catheterisation or liver stiffness in idiopathic portal hypertension. METHODS: 39 cases of idiopathic portal hypertension patients were retrospectively reviewed. Hepatic vein catheterisation and liver stiffness measurements were compared to matched patients with cirrhosis and portal hypertension, and non-cirrhotic portal vein thrombosis, included as controls. RESULTS: Hepatic vein-to-vein communications were found in 49% idiopathic portal hypertension patients precluding adequate hepatic venous pressure gradient measurements in 12. In the remaining 27 patients, mean hepatic venous pressure gradient (HVPG) was 7.1±3.1mmHg. Only 5 patients had HVPG≥10mmHg. HVPG was markedly lower than in cirrhosis (17±3mmHg, p<0.001). Mean liver stiffness in idiopathic portal hypertension was 8.4±3.3kPa; significantly higher than in non-cirrhotic portal vein thrombosis (6.4±2.2kPa, p=0.009), but lower than in cirrhosis (40.9±20.5kPa, p=0.005). Only 2 idiopathic portal hypertension patients had liver stiffness >13.6kPa. CONCLUSIONS: Patients with idiopathic portal hypertension frequently have hepatic vein-to-vein communications and, despite unequivocal signs of portal hypertension, HVPG and liver stiffness values much lower than the cut-off for clinical significant portal hypertension in cirrhosis. These findings oblige to formally rule-out idiopathic portal hypertension in the presence of signs of portal hypertension.
Authors:
Susana Seijo; Enric Reverter; Rosa Miquel; Annalisa Berzigotti; Juan G Abraldes; Jaume Bosch; Juan Carlos García-Pagán
Related Documents :
7257019 - Percutaneous upper urinary tract dynamics in equivocal obstruction.
12857509 - Use of a self-designed bladder controller for restoring bladder function in paraplegic ...
37349 - Pressor response during cystomanometry in spinal injury patients complicated with detru...
15217449 - The role of the rhabdosphincter in female rat voiding.
16224799 - Selective activation of the sacral anterior roots for induction of bladder voiding.
12410759 - Contralateral response in renal pelvic pressure and diuresis during increasing ipsilate...
280849 - Effect of renovascular hypertension of the morphology of oral blood vessels.
22108149 - Impact of lipid profile and high blood pressure on endothelial damage.
7435539 - The failure of furosemide-induced salt and water loss to convert benign to malignant hy...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  -     ISSN:  1878-3562     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Women with pre-existing diabetes and their experiences of maternity care services.
Next Document:  A(?B)AR expression in non-immune cells plays an important role in the development of murine colitis.