Document Detail

Role of the hepatic artery in canalicular bile formation by the perfused rat liver. A multiple indicator dilution study.
MedLine Citation:
PMID:  3284914     Owner:  NLM     Status:  MEDLINE    
The role of the hepatic artery in tracer water exchange and regulation of permeation of small solutes during canalicular bile formation was studied in the rat using a system that permitted perfusion of both hepatic artery and portal vein. Hepatic vein and biliary multiple indicator dilution curves were obtained after injection of indicators into either vessel. The main difference in hepatic venous dilution curves was a 3.1-fold longer t0 (time spent in nonexchanging vessels) and a 5% larger equivalent water space after injection into the hepatic artery. Biliary tracer recovery of water was markedly higher after arterial injection than after portal vein injection. Both taurocholate and taurodehydrocholate stimulated bile flow and increased biliary tracer recovery after injection into either vessel. The biliary recovery of sucrose relative to that of water, which is a measure of biliary sucrose permeation, was much lower when given into the hepatic artery than when given into the portal vein. During taurocholate infusion, it decreased by 33% in the hepatic artery but increased 36% in the portal vein. Taurodehydrocholate, by contrast, did not affect permeation of sucrose given into the portal vein. Our studies demonstrate marked exchange of tracer water in the biliary epithelium. Taurocholate, but not taurodehydrocholate, increases permeation of sucrose into bile in the portal vein bed while both bile salts decrease it in the arterial bed.
J Reichen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  81     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-14     Completed Date:  1988-06-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1462-9     Citation Subset:  AIM; IM    
Department of Clinical Pharmacology, University of Berne, Switzerland.
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MeSH Terms
Bile / secretion*
Bile Canaliculi / secretion*
Bile Ducts, Intrahepatic / secretion*
Body Water / metabolism
Deoxycholic Acid / analogs & derivatives*
Hepatic Artery / physiology*
Indicator Dilution Techniques
Portal Vein / physiology
Rats, Inbred Strains
Sucrose / metabolism
Taurocholic Acid / metabolism*
Taurodeoxycholic Acid / metabolism*
Reg. No./Substance:
0/Micelles; 516-50-7/Taurodeoxycholic Acid; 57-50-1/Sucrose; 81-24-3/Taurocholic Acid; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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