Document Detail

Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
MedLine Citation:
PMID:  17368428     Owner:  NLM     Status:  MEDLINE    
The developmental biology of the dopamine (DA) system may hold important clues to its reconstruction. We hypothesized that factors highly expressed during nigrostriatal development and re-expressed after injury and disease may play a role in protection and reconstruction of the nigrostriatal system. Examination of gene expression in the developing striatum suggested an important role for the heparin binding growth factor family at time points relevant to establishment of dopaminergic innervation. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during development. Furthermore, PTN was up-regulated in the degenerating substantia nigra of Parkinson's patients. The addition of PTN to ventral mesencephalic cultures augmented DA neuron survival and neurite outgrowth. Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system.
Deanna M Marchionini; Elin Lehrmann; Yaping Chu; Bin He; Caryl E Sortwell; Kevin G Becker; William J Freed; Jeffrey H Kordower; Timothy J Collier
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-02-22
Journal Detail:
Title:  Brain research     Volume:  1147     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-07-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-88     Citation Subset:  IM    
Dept. Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / metabolism
Carrier Proteins / genetics,  metabolism*
Case-Control Studies
Cytokines / genetics,  metabolism*
Dopamine / metabolism*
Gene Expression Regulation
Neostriatum / cytology,  growth & development,  metabolism*
Parkinson Disease / metabolism*
Rats, Inbred F344
Receptor Protein-Tyrosine Kinases / metabolism
Reference Values
Substantia Nigra / cytology,  growth & development,  metabolism*
Supranuclear Palsy, Progressive / metabolism
Syndecan-3 / metabolism
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Cytokines; 0/Syndecan-3; 134034-50-7/pleiotrophin; 137497-38-2/midkine; EC Protein-Tyrosine Kinases

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