Document Detail


Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
MedLine Citation:
PMID:  17368428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The developmental biology of the dopamine (DA) system may hold important clues to its reconstruction. We hypothesized that factors highly expressed during nigrostriatal development and re-expressed after injury and disease may play a role in protection and reconstruction of the nigrostriatal system. Examination of gene expression in the developing striatum suggested an important role for the heparin binding growth factor family at time points relevant to establishment of dopaminergic innervation. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during development. Furthermore, PTN was up-regulated in the degenerating substantia nigra of Parkinson's patients. The addition of PTN to ventral mesencephalic cultures augmented DA neuron survival and neurite outgrowth. Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system.
Authors:
Deanna M Marchionini; Elin Lehrmann; Yaping Chu; Bin He; Caryl E Sortwell; Kevin G Becker; William J Freed; Jeffrey H Kordower; Timothy J Collier
Related Documents :
20045938 - The involvement of aldose reductase in alterations to neurotrophin receptors and neuron...
18627098 - Xenopus zinc finger transcription factor ia1 (insm1) expression marks anteroventral nor...
10383828 - Differences and developmental changes in the responsiveness of pns neurons to gdnf and ...
22482968 - Estrogen receptor expression affected by hypoxia inducible factor-1α in stromal cells f...
23665588 - Zebrafish transforming growth factor-ß-stimulated clone 22 domain 3 (tsc22d3) plays cri...
17151798 - Loss of mal expression in precancerous lesions of the esophagus.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-02-22
Journal Detail:
Title:  Brain research     Volume:  1147     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-07-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-88     Citation Subset:  IM    
Affiliation:
Dept. Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA. deanna_marchionini@rush.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / metabolism
Animals
Carrier Proteins / genetics,  metabolism*
Case-Control Studies
Cytokines / genetics,  metabolism*
Dopamine / metabolism*
Female
Gene Expression Regulation
Humans
Male
Neostriatum / cytology,  growth & development,  metabolism*
Parkinson Disease / metabolism*
Rats
Rats, Inbred F344
Receptor Protein-Tyrosine Kinases / metabolism
Reference Values
Substantia Nigra / cytology,  growth & development,  metabolism*
Supranuclear Palsy, Progressive / metabolism
Syndecan-3 / metabolism
Grant Support
ID/Acronym/Agency:
NS42125/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Cytokines; 0/Syndecan-3; 134034-50-7/pleiotrophin; 137497-38-2/midkine; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pain-related behavior following REM sleep deprivation in the rat: influence of peripheral nerve inju...
Next Document:  Inherited tertiary hypothyroidism in Sprague-Dawley rats.