Document Detail

Role of hematocrit in the recruitment of pulmonary diffusing capacity: comparison of human and dog.
MedLine Citation:
PMID:  8964719     Owner:  NLM     Status:  MEDLINE    
In dogs, maximal O2 uptake (VO2max) per kilogram of body weight is two- to threefold that in humans; the difference cannot be explained solely by differences in structural features between species. We compared the functional recruitment of pulmonary diffusing capacity (DLCO) during exercise in dogs with that in humans to determine whether pulmonary gas exchange is matched to VO2max or the size of the lungs and to define the potential role of exercise-induced polycythemia in producing the superior aerobic capacity of the dogs. We compared the relationships of DLCO, membrane diffusing capacity (DMCO), and pulmonary capillary blood volume (Vc) with respect to pulmonary blood flow (Qc) by a rebreathing method during steady-state exercise in adult male human subjects and in conditioned adult male foxhounds. The slopes and intercepts of the relationships of DLCO and DMCO to Qc are significantly greater in dogs than in humans; the slopes of the relationship of Vc to Qc are similar. In dogs diffusive pulmonary gas transport is matched to the higher VO2max. The enhanced recruitment of DLCO and DMCO in dogs during exercise could potentially be explained entirely by the exercise-induced polycythemia, which is seen in dogs but not in humans.
E Y Wu; M Ramanathan; C C Hsia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  80     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1014-20     Citation Subset:  IM; S    
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA.
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MeSH Terms
Blood Flow Velocity / physiology
Linear Models
Middle Aged
Oxygen / metabolism*
Pulmonary Circulation / physiology*
Pulmonary Gas Exchange / physiology*
Grant Support
Reg. No./Substance:
Erratum In:
J Appl Physiol 1996 Jun;80(6):1849

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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