Document Detail

Role of the gut microbiota in immunity and inflammatory disease.
MedLine Citation:
PMID:  23618829     Owner:  NLM     Status:  MEDLINE    
The mammalian intestine is colonized by trillions of microorganisms, most of which are bacteria that have co-evolved with the host in a symbiotic relationship. The collection of microbial populations that reside on and in the host is commonly referred to as the microbiota. A principal function of the microbiota is to protect the intestine against colonization by exogenous pathogens and potentially harmful indigenous microorganisms via several mechanisms, which include direct competition for limited nutrients and the modulation of host immune responses. Conversely, pathogens have developed strategies to promote their replication in the presence of competing microbiota. Breakdown of the normal microbial community increases the risk of pathogen infection, the overgrowth of harmful pathobionts and inflammatory disease. Understanding the interaction of the microbiota with pathogens and the host might provide new insights into the pathogenesis of disease, as well as novel avenues for preventing and treating intestinal and systemic disorders.
Nobuhiko Kamada; Sang-Uk Seo; Grace Y Chen; Gabriel Núñez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-06-24     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-35     Citation Subset:  IM    
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MeSH Terms
Gastrointestinal Tract / immunology*,  microbiology*
Host-Pathogen Interactions / immunology
Inflammation / immunology,  microbiology
Intestinal Mucosa / immunology,  microbiology
Metagenome / immunology*
Symbiosis / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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