Document Detail


Role of the gut microbiota in the development and function of lymphoid cells.
MedLine Citation:
PMID:  23378581     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammals are colonized by large numbers of microorganisms, including trillions of bacteria, most of which live in the intestinal tract. These indigenous microorganisms that inhabit the body of humans and animals are referred collectively to as the microbiota. Accumulating evidence indicates that the microbiota regulates the development and/or function of different types of immune cells in the intestine. For example, the microbiota drives homeostatic, pathogenic, and regulatory T cell immune responses that contribute to tissue homeostasis, but also can promote disease. The gut microbes also facilitate IgA responses, which in turn regulate the composition and function of the gut microbiota. Thus, the reciprocal regulation of the gut microbiota and the host immune system may influence the balance between homeostasis and disease in the intestine.
Authors:
Nobuhiko Kamada; Gabriel Núñez
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  190     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-03-28     Revised Date:  2014-09-26    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1389-95     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / immunology*
Homeostasis / immunology
Humans
Immunoglobulin A / biosynthesis
Intestinal Diseases / immunology,  microbiology,  pathology
Intestinal Mucosa / cytology,  immunology*,  microbiology*
T-Lymphocyte Subsets / cytology,  immunology*,  microbiology*
Grant Support
ID/Acronym/Agency:
P30 DK034933/DK/NIDDK NIH HHS; R01 AI063331/AI/NIAID NIH HHS; R01 AR059688/AR/NIAMS NIH HHS; R01 DK061707/DK/NIDDK NIH HHS; R01 DK091191/DK/NIDDK NIH HHS; R01 DK091191/DK/NIDDK NIH HHS; R01 DK095782/DK/NIDDK NIH HHS; R01 DK61707/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin A
Comments/Corrections

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