Document Detail

Role of growth factors in acute renal failure.
MedLine Citation:
PMID:  9269628     Owner:  NLM     Status:  MEDLINE    
EGF, IGF-I, and HGF are involved in the endogenous tissue repair after acute renal injury. All three growth factors accelerate the recovery of renal function and the anatomical restoration of tubular integrity when given exogenously to laboratory animals with experimental ARF. However, clinical study of the therapeutic efficacy of recombinant peptide growth factors in ARF is limited to rhIGF-I. Both clinical trials of rhIGF-I in patients with ARF have been indeterminant or negative. Thus, the therapeutic use of peptide growth factors may not be the magic bullet for the cure of a disease that contributes significantly to morbidity and mortality in severely ill patients. However, there is ample experimental basis for further clinical study of recombinant human peptide growth factors in ARF.
S Wang; R Hirschberg
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  12     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-09     Completed Date:  1997-10-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1560-3     Citation Subset:  IM    
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MeSH Terms
Growth Substances / physiology*
Hemodynamics / physiology
Insulin-Like Growth Factor I / therapeutic use
Kidney Failure, Acute / etiology*
Kidney Tubules / pathology,  physiopathology
Nephrons / blood supply
Recombinant Proteins / therapeutic use
Reg. No./Substance:
0/Growth Substances; 0/Recombinant Proteins; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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