Document Detail


Role of the gonads in the regulation of sebaceous glands in rats: comparison of the effects of castration at and after birth.
MedLine Citation:
PMID:  7400714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sprague-Dawley rats were castrated either within 24 h of birth or at 4 weeks of age. Control animals were sham operated. Intact female rats were also included for comparison. Sebum production was assessed at 80 days of age by measuring the amount of skin-surface lipids that could be extracted with acetone and which had been produced during 2 days. The removal of the testes at birth reduced the activity of the sebaceous glands to level more nearly approaching that seen in the female rats whereas castration at 4 weeks of age only partially decreased the rate of sebum secretion so that it was intermediate between the male and female rats. The weights of the pituitary gland, thyroid and adrenal glands increased after castration but there were no differences between rats castrated at birth and those castrated at 4 weeks of age except in the weight of the thyroid gland. It would appear that the role of the testes in the control of the activity of the sebaceous glands is a sequential event which has already started at birth.
Authors:
Y C Toh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  85     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Castration*
Endocrine Glands / anatomy & histology
Female
Male
Organ Size
Rats
Sebaceous Glands / physiology*
Sebum / secretion
Testis / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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