Document Detail

Role of gonadotropin-releasing hormone antagonist in the management of subfertile couples with intrauterine insemination and controlled ovarian stimulation.
MedLine Citation:
PMID:  21334613     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether the clinical pregnancy rate of patients treated with recombinant FSH and IUI can be improved by the addition of a GnRH antagonist.
DESIGN: Prospective, controlled study.
SETTING: Reproductive medicine clinic.
PATIENT(S): Ninety-three patients with primary or secondary infertility.
INTERVENTION(S): Patients were allocated to controlled ovarian stimulation with recombinant FSH (50-150 IU/d) only (control group, n=45) or to recombinant FSH (50-150 IU/d) plus ganirelix (0.25 mg/d, starting when the leading follicle was ≥16 mm; n=48). A single insemination was performed 36 hours after hCG was given (10,000 IU, IM) in both groups. Both groups were allowed at least three cycles.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate, premature luteinization rate, and follicular development.
RESULT(S): Clinical pregnancy rate (22% vs. 11%), cumulative pregnancy rate (52% vs. 31%), and number of mature follicles (2.1±1.08 vs. 1.4±0.95) were statistically significantly higher in the ganirelix group compared with the control group. The premature luteinization rate was significantly lower in the ganirelix group (1.7% vs. 17.5%).
CONCLUSION(S): The use of a GnRH antagonist in conjunction with controlled ovarian stimulation and IUI significantly increases pregnancy rates and reduces the incidence of premature luteinization.
Panagiotis Bakas; Sokratis Konidaris; Angelos Liapis; Odyseas Gregoriou; Despoina Tzanakaki; Georgios Creatsas
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2011-02-19
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-20     Completed Date:  2011-06-21     Revised Date:  2011-09-07    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2024-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Second Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Athens, Greece.
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MeSH Terms
Family Characteristics
Fertility Agents, Female / administration & dosage,  therapeutic use
Follicle Stimulating Hormone / administration & dosage,  therapeutic use
Gonadotropin-Releasing Hormone / administration & dosage,  analogs & derivatives,  antagonists & inhibitors*,  therapeutic use
Hormone Antagonists / administration & dosage,  therapeutic use*
Infertility / drug therapy,  therapy*
Insemination, Artificial / methods*
Ovulation Induction / methods*
Pregnancy Rate
Recombinant Proteins / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Fertility Agents, Female; 0/Hormone Antagonists; 0/Recombinant Proteins; 123246-29-7/ganirelix; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-68-0/Follicle Stimulating Hormone
Comment In:
Fertil Steril. 2011 Aug;96(2):e133; author reply e134   [PMID:  21669412 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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