| Role of gonadotropin-releasing hormone antagonist in the management of subfertile couples with intrauterine insemination and controlled ovarian stimulation. | |
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MedLine Citation:
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PMID: 21334613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether the clinical pregnancy rate of patients treated with recombinant FSH and IUI can be improved by the addition of a GnRH antagonist. DESIGN: Prospective, controlled study. SETTING: Reproductive medicine clinic. PATIENT(S): Ninety-three patients with primary or secondary infertility. INTERVENTION(S): Patients were allocated to controlled ovarian stimulation with recombinant FSH (50-150 IU/d) only (control group, n=45) or to recombinant FSH (50-150 IU/d) plus ganirelix (0.25 mg/d, starting when the leading follicle was ≥16 mm; n=48). A single insemination was performed 36 hours after hCG was given (10,000 IU, IM) in both groups. Both groups were allowed at least three cycles. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate, premature luteinization rate, and follicular development. RESULT(S): Clinical pregnancy rate (22% vs. 11%), cumulative pregnancy rate (52% vs. 31%), and number of mature follicles (2.1±1.08 vs. 1.4±0.95) were statistically significantly higher in the ganirelix group compared with the control group. The premature luteinization rate was significantly lower in the ganirelix group (1.7% vs. 17.5%). CONCLUSION(S): The use of a GnRH antagonist in conjunction with controlled ovarian stimulation and IUI significantly increases pregnancy rates and reduces the incidence of premature luteinization. |
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Authors:
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Panagiotis Bakas; Sokratis Konidaris; Angelos Liapis; Odyseas Gregoriou; Despoina Tzanakaki; Georgios Creatsas |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2011-02-19 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-20 Completed Date: 2011-06-21 Revised Date: 2011-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2024-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Second Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Athens, Greece. p_bakas@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Family Characteristics Female Fertility Agents, Female / administration & dosage, therapeutic use Follicle Stimulating Hormone / administration & dosage, therapeutic use Gonadotropin-Releasing Hormone / administration & dosage, analogs & derivatives, antagonists & inhibitors*, therapeutic use Hormone Antagonists / administration & dosage, therapeutic use* Humans Infertility / drug therapy, therapy* Insemination, Artificial / methods* Male Ovulation Induction / methods* Pregnancy Pregnancy Rate Recombinant Proteins / administration & dosage, therapeutic use Uterus |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 0/Hormone Antagonists; 0/Recombinant Proteins; 123246-29-7/ganirelix; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-68-0/Follicle Stimulating Hormone |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 2011 Aug;96(2):e133; author reply e134
[PMID:
21669412
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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