| Role of glutathione in cell nucleus. | |
| | |
MedLine Citation:
|
PMID: 20528574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cells with high proliferation rate have high glutathione levels. This typical feature of cancer cells is viewed usually as a defence mechanism against ionizing radiation or chemotherapy. Efforts have been made in order to decrease cellular glutathione levels in tumours as a necessary pre-treatment for cancer therapy. However, very few reports have considered cellular glutathione as a physiological tool for cells to proliferate and that most of this high glutathione levels were located in the nucleus. The role of nuclear glutathione in cell physiology has become more important in the last years. This review summarizes new findings that point to the nuclear reduced status as an environment that induces heterochromatin formation. Glutathionylation and oxidation of nuclear proteins appear as a reversible physiological mechanism able to regulate DNA compaction, cell cycle and DNA repair. |
| | |
Authors:
|
Jelena Markovic; José Luís García-Gimenez; Amparo Gimeno; José Viña; Federico V Pallardó |
Related Documents
:
|
21533504 - Stimulation of beta-adrenoceptor enhances sensitivity to cisplatin in non-small cell lu... 19043054 - Hypotaurine and sulfhydryl-containing antioxidants reduce h2s toxicity in erythrocytes ... 18562474 - Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of frie... 20650204 - Protective roles of glutathione in the toxicity of mercury and cadmium compounds to c6 ... 15703624 - Cell and molecular biology of the small intestine: new insights into differentiation, g... 11053294 - Eiu in the rat promotes the potential of syngeneic retinal cells injected into the vitr... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Free radical research Volume: 44 ISSN: 1029-2470 ISO Abbreviation: Free Radic. Res. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-10 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
|
Languages: eng Pagination: 721-33 Citation Subset: IM |
Affiliation:
|
Department of Physiology, University of Valencia, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle / physiology Cell Nucleus / metabolism* DNA / metabolism DNA Repair Glutathione / physiology* Heterochromatin / metabolism Histones / metabolism Humans Nuclear Proteins / metabolism Oxidation-Reduction Protein Carbonylation Protein Processing, Post-Translational Telomerase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Heterochromatin; 0/Histones; 0/Nuclear Proteins; 70-18-8/Glutathione; 9007-49-2/DNA; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case report of subacute thyroiditis during pregnancy: difficulties in differential diagnosis and c...
Next Document: Effect of CRH on NO bioavailability, ROS production and antioxidant defense systems in endothelial E...