Document Detail


Role of ghrelin in the pathophysiology of eating disorders: implications for pharmacotherapy.
MedLine Citation:
PMID:  22452525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ghrelin is the only known circulating orexigenic hormone. It increases food intake by interacting with hypothalamic and brainstem circuits involved in energy balance, as well as reward-related brain areas. A heightened gut-brain ghrelin axis is an emerging feature of certain eating disorders such as anorexia nervosa and Prader-Willi syndrome. In common obesity, ghrelin levels are lowered, whereas post-meal ghrelin levels remain higher than in lean individuals. Agents that interfere with ghrelin signalling have therapeutic potential for eating disorders, including obesity. However, most of these drugs are only in the preclinical phase of development. Data obtained so far suggest that ghrelin agonists may have potential in the treatment of anorexia nervosa, while ghrelin antagonists seem promising for other eating disorders such as obesity and Prader-Willi syndrome. However, large clinical trials are needed to evaluate the efficacy and safety of these drugs.
Authors:
Sebastian Cardona Cano; Myrte Merkestein; Karolina P Skibicka; Suzanne L Dickson; Roger A H Adan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  CNS drugs     Volume:  26     ISSN:  1172-7047     ISO Abbreviation:  CNS Drugs     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-28     Completed Date:  2012-07-23     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9431220     Medline TA:  CNS Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  281-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia Nervosa / drug therapy,  physiopathology
Brain / metabolism
Eating Disorders / drug therapy,  physiopathology*
Ghrelin / agonists,  antagonists & inhibitors,  metabolism*
Humans
Obesity / drug therapy,  physiopathology*
Prader-Willi Syndrome / drug therapy,  physiopathology
Reward
Signal Transduction / drug effects
Chemical
Reg. No./Substance:
0/Ghrelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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