Document Detail

Role of gastrin as a trophic hormone.
MedLine Citation:
PMID:  2093009     Owner:  NLM     Status:  MEDLINE    
Gastrin has two principal biological effects: stimulation of acid secretion from gastric parietal cells and stimulation of mucosal growth in the acid-secreting part of the stomach. Circulating gastrin regulates the increase in acid secretion that occurs during the after meals. Gastrin also stimulates mucosal growth in the stomach. Exogenously administered gastrin causes increased cell division in the proliferative zone that lies between the surface cells and the gastric glands in the acid-secreting mucosa. The newly formed cells undergo differentiation into surface epithelial cells, parietal cells and gastric enterochromaffin-like cells. Furthermore, the increased mucosal proliferation that occurs with refeeding after a period of fasting may be mediated by gastrin since refeeding stimulates gastrin production and a parallel increase in mucosal DNA synthesis. Both food and gastrin cause a rapid increase in cell division and an increase in gastric ornithine decarboxylase mRNA in fasting rats. In preliminary immunoneutralization experiments, the stimulation of ornithine decarboxylase produced by food was inhibited by gastrin antibody. The sustained inhibition of gastric acid secretion obtained by surgery or with antisecretory drug therapy results in hypergastrinaemia associated with increased gastric mucosal cell proliferation. A good correlation between gastric enterochromaffin-like cell density and circulating gastrin concentrations has been found under these conditions as well as during infusions of exogenous gastrin. Trophic effects of gastrin have also been reported for the colon, duodenum and pancreas, but chronic hypergastrinaemia does not appear to produce hyperplasia of these organs.(ABSTRACT TRUNCATED AT 250 WORDS)
J H Walsh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Digestion     Volume:  47 Suppl 1     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1990  
Date Detail:
Created Date:  1991-06-18     Completed Date:  1991-06-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  11-6; discussion 49-52     Citation Subset:  IM    
Center for Ulcer Research and Education, Wadsworth Veterans Administration Center, Los Angeles, Calif.
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MeSH Terms
Cell Division / drug effects
Gastric Acid / secretion*
Gastric Mucosa / cytology,  drug effects
Gastrins / pharmacology,  physiology*
Omeprazole / pharmacology
Parietal Cells, Gastric / secretion*
Reg. No./Substance:
0/Gastrins; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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