Document Detail

Role of gastric sensorimotor dysfunction in gastrointestinal symptoms and energy intake in liver cirrhosis.
MedLine Citation:
PMID:  17327944     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Altered gastric sensorimotor function is related to the symptomatology in several gastrointestinal diseases. Gastrointestinal symptoms in patients with cirrhosis may result in low energy intake contributing to malnutrition and increased morbidity. The aim of this study was to investigate gastric accommodation to a meal and sensitivity to gastric distension with reference to energy intake, nutritional status and gastrointestinal symptoms in liver cirrhosis. MATERIAL AND METHODS: Sixteen patients with cirrhosis and 15 healthy controls underwent a gastric barostat study to assess gastric accommodation to a meal and sensory thresholds for first perception and discomfort. The patients also underwent a slow caloric satiety drinking test. Food intake and nutritional status were also evaluated and gastrointestinal symptoms were assessed by means of a questionnaire. RESULTS: Compared with controls, patients with cirrhosis had enhanced gastric accommodation (p<0.05) but lower daily energy intake (p<0.05). Patients with versus those without compromised nutritional status had enhanced gastric accommodation (p<0.05). Gastric accommodation was correlated to daily energy intake in controls (r=0.67, p<0.05) but not in cirrhotic patients (p>0.4). The end-point of the satiety test was inversely related to gastric volumes in cirrhotic patients. Mean post-meal balloon volumes were positively correlated to the Model for End Stage Liver Disease (MELD) score (r=0.53, p<0.05). Sensory thresholds did not differ between patients and controls but were related to gastrointestinal symptom severity and cirrhosis severity scores in the patients. CONCLUSIONS: Gastric accommodation is increased in cirrhotic patients but there seems to be some disturbance in its relation to energy intake. The satiety drinking test is not a good surrogate marker of accommodation in cirrhotic patients. In cirrhosis the severity of gastrointestinal symptoms is related to gastric sensitivity.
Evangelos Kalaitzakis; Magnus Simrén; Hasse Abrahamsson; Einar Björnsson
Related Documents :
20965184 - Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, ...
19561114 - Incomplete carney triad--a review of two cases.
22870564 - A cost effective complement to managing the vitamin d deficient and anemic dialysis pat...
19291424 - Regulatory t cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis.
3863354 - Studies on granulocyte functions in patients with chronic myeloid leukemia.
11774944 - An open-label trial of the ppar-gamma ligand rosiglitazone for active ulcerative colitis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  42     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-28     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  237-46     Citation Subset:  IM    
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Physiological / physiology*
Disease Progression
Energy Intake / physiology*
Gastric Emptying / physiology*
Liver Cirrhosis / metabolism*,  physiopathology*
Middle Aged
Severity of Illness Index
Stomach / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of the Danish national strategy for selective use of colonoscopy in symptomatic outpatien...
Next Document:  Prediction of sustained virological response in chronic hepatitis C patients treated with peginterfe...