| Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | |
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MedLine Citation:
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PMID: 11334548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical usefulness of doxorubicin is limited by cardiotoxicity. We have demonstrated that doxorubicin has a dual negative effect on myocardial lipids, acting against highly unsaturated fatty acids (HUFAs) directly and desaturating/elongating enzymes required for their biosynthesis, thus decreasing linoleic and alpha -linolenic conversion to higher metabolites. Primary cultures of rat cardiomyocytes were challenged with different doxorubicin concentrations and doxorubicin exposure was followed by a 24-h recovery period in the absence or presence of serum, and of gamma -linolenic acid. Serum in the recovery medium did not appear to be essential for the restoration of the desaturating/elongating activities, and gamma -linolenic acid supplementation influenced only alpha -linolenic acid conversion. Serum, and particularly gamma-linolenic acid, were very important in increasing HUFA levels behind the pure biosynthesis. HUFA biosynthesis plays a role in counteracting doxorubicin toxicity, but it cannot completely overcome the depletion of these fatty acids; serum and exogenous gamma-linolenate are critical in filling the decreased HUFA pool. |
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Authors:
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S Hrelia; A Bordoni; P L Biagi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 64 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-05-03 Completed Date: 2001-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Harcourt Publishers Ltd. |
Affiliation:
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Dipartimento di Biochimica G. Moruzzi, University of Bologna, Bologna, Italy. hrelia@biocfarm.unibo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / adverse effects, pharmacology Cells, Cultured Dose-Response Relationship, Drug Doxorubicin / adverse effects, pharmacology* Fatty Acids, Unsaturated / metabolism Myocardium / cytology*, metabolism Rats Rats, Wistar Time Factors alpha-Linolenic Acid / metabolism gamma-Linolenic Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Fatty Acids, Unsaturated; 23214-92-8/Doxorubicin; 463-40-1/alpha-Linolenic Acid; 506-26-3/gamma-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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