Document Detail


Role of gallbladder mucin in pathophysiology of gallstones.
MedLine Citation:
PMID:  6546237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A critical step in the formation of cholesterol gallstones in nucleation (i.e., the formation of cholesterol monohydrate crystals from supersaturated bile). The rate of nucleation of cholesterol depends upon a critical balance between pronucleating and antinucleating factors in bile. Mucin, a high molecular weight glycoprotein secreted by the gallbladder and biliary duct epithelium, is a pronucleating agent in experimental and human gallstone disease. Gallbladder mucin shares with other epithelial mucins the ability to bind lipids and bile pigment. The hydrophobic binding sites in the polypeptide core of mucin may provide a favorable environment for nucleation of cholesterol monohydrate from supersaturated bile. In nearly all animal models of cholelithiasis, mucin hypersecretion is prominent. The stimulus for gallbladder mucin hypersecretion appears to be a component of lithogenic bile. Prostaglandins regulate mucin release in gallbladder epithelium in vitro and probably in vivo. In the cholesterol-fed prairie dog, blockage of mucin release with aspirin inhibits gallstone formation. These findings suggest that inhibition of mucin release may prevent cholesterol stone formation during high-risk periods or after dissolution therapy with bile salts.
Authors:
J T LaMont; B F Smith; J R Moore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  4     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:    1984 Sep-Oct
Date Detail:
Created Date:  1984-11-13     Completed Date:  1984-11-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51S-56S     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile / analysis
Cholelithiasis / etiology,  metabolism,  physiopathology*
Cholesterol / metabolism
Crystallization
Gallbladder / secretion*
Humans
Lipids / analysis
Mucins / analysis,  physiology*,  secretion
Sciuridae
Grant Support
ID/Acronym/Agency:
AM 06995/AM/NIADDK NIH HHS; AM 29195/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Lipids; 0/Mucins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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