Document Detail

Role of foods in irregular aggravation of skin lesions in children with atopic dermatitis.
MedLine Citation:
PMID:  18705827     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis is a common inflammatory skin disease that especially affects children and adolescents. Many environmental factors have been recognized as relevant in aggravating skin lesions of the disease. However, it remains to be determined whether foods play a role in worsening of skin lesions in children with atopic dermatitis. In the present study, we investigated whether foods play a role in irregular aggravation of skin lesions in children with the disease. The study population consisted of 69 patients aged 3-15 years with atopic dermatitis. They were hospitalized and open challenge tests were performed with suspected foods. Photographs of representative skin lesion sites were taken at baseline and before and after the challenge. We determined challenge-positive foods by evaluating the comparable before/after challenge photographs. One to three (average, 1.9) challenge-positive foods were confirmed in 52 (75%) of the 69 patients examined. Predominant offending foods were chocolate, cheese and yogurt. Specific immunoglobulin E values to offending foods were mostly negative. We asked patients to exclude challenge-positive foods from their diets. They were then discharged and followed up for 3 months at our outpatient clinic. Exclusion of the offending foods for 3 months brought about a remarkable improvement in the disease. These results suggest that foods play an important role in irregular aggravation of skin lesions in children with atopic dermatitis.
Toshiaki Uenishi; Hisashi Sugiura; Toshihiro Tanaka; Masami Uehara
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  35     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  407-12     Citation Subset:  IM    
Department of Dermatology, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan.
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MeSH Terms
Child, Preschool
Cohort Studies
Dermatitis, Atopic / diet therapy*,  pathology*
Food / adverse effects*
Severity of Illness Index

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