Document Detail

Role of food type in yohimbine- and pellet-priming-induced reinstatement of food seeking.
MedLine Citation:
PMID:  16806322     Owner:  NLM     Status:  MEDLINE    
We have recently adapted a reinstatement model, commonly used to study relapse to drugs of abuse, to study the role of stress and anxiety in relapse to palatable food seeking [Ghitza UE, Gray SM, Epstein DH, Rice KC, Shaham Y. The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF(1) receptors. Neuropsychopharmacology [in press]]. We found that the anxiogenic drug yohimbine, as well as pellet-priming, reinstate food seeking in food restricted rats previously trained to lever press for palatable food pellets (25% fat, 48% carbohydrate). Here, we studied the generality of the effect of yohimbine and pellet priming on reinstatement of food seeking by using three distinct pellet types: non-sucrose carbohydrate (NSC) (5.5% fat, 60% carbohydrate, 4.5% fiber), fiber (0% fat, 0% carbohydrate, 91% fiber) and sucrose (0% fat, 91% carbohydrate, 4% fiber). Rats were placed on a restricted diet (75-80% of daily standard food) and for 9-12 intermittent training days (9 h/day, every other day) lever-pressed for the food pellets under a fixed ratio-1 (20-s timeout) reinforcement schedule. Subsequently, the rats were given 9-10 daily extinction sessions during which lever-presses were not reinforced, and were then injected with yohimbine (0, 0.5, 1.0, 2.0 mg/kg, i.p.) or given a single food pellet to induce reinstatement of food seeking. Yohimbine reinstated food seeking previously reinforced by NSC and sucrose pellets, but had a minimal effect on food seeking in rats previously trained to lever press for fiber pellets. Pellet priming produced a greater degree of reinstatement of lever pressing in rats previously trained on NSC pellets than in rats trained on fiber or sucrose pellets. Results suggest that the magnitude of the effect of yohimbine and pellet priming on reinstatement of food seeking depends in part on the composition of the food pellets used during training.
S G Nair; S M Gray; U E Ghitza
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2006-06-27
Journal Detail:
Title:  Physiology & behavior     Volume:  88     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-28     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  559-66     Citation Subset:  IM    
Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, National Institutes of Health, Baltimore, MD 21224, USA.
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MeSH Terms
Caloric Restriction / psychology
Conditioning, Operant / drug effects
Data Interpretation, Statistical
Dietary Carbohydrates / pharmacology
Dietary Fats / pharmacology
Dietary Fiber / pharmacology
Extinction, Psychological / drug effects
Feeding Behavior / drug effects*
Rats, Long-Evans
Self Administration
Sucrose / pharmacology
Sympatholytics / pharmacology*
Yohimbine / pharmacology*
Grant Support
Z01 DA000434-06/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Sympatholytics; 146-48-5/Yohimbine; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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