| Role of food protein intolerance in infants with persistent distress attributed to reflux esophagitis. | |
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MedLine Citation:
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PMID: 10802497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Distressed behavior is common in infants and is often attributed to gastroesophageal reflux (GER) or food protein intolerance. OBJECTIVE: To examine the effect of a hypoallergenic amino acid-based infant formula (AAF) on distressed behavior and GER symptoms in infants who failed to respond to extensively hydrolyzed formula and antireflux medications. STUDY DESIGN: Nineteen distressed infants (9 boys and 10 girls; median age, 5.0 months) with presumed GER underwent gastroscopy (n = 17) and esophageal 24-hour pH monitoring (n = 14). Double-blind placebo-controlled (DBPC) formula challenges of AAF versus previously besttolerated formula were conducted. RESULTS: Nine infants had histologic evidence of esophagitis, and 9 had inflammatory changes in the stomach and/or duodenum. Symptoms remitted in all infants within 2 weeks of the start of feeding with AAF. On DBPC challenge after a median period of 3 months of receiving AAF, 12 infants were intolerant to active formula (distress score, 287 vs 580 min/wk,P =. 01; symptom score, 23.1 vs 36.1, P =.03). Seven infants did not relapse and were considered tolerant (distress score, 470 vs 581, P =.77; symptom score, 29.5 vs 20.2; P =.89). CONCLUSION: Treatment with AAF may reduce distressed behavior and symptoms of GER in infants with food protein intolerance. |
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Authors:
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D J Hill; R G Heine; D J Cameron; A G Catto-Smith; C W Chow; D E Francis; C S Hosking |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 136 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-23 Completed Date: 2000-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 641-7 Citation Subset: AIM; IM |
Affiliation:
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Departments of Allergy, Gastroenterology & Clinical Nutrition, and Anatomical Pathology, Royal Children's Hospital, Melbourne, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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therapeutic use Dietary Proteins / adverse effects* Double-Blind Method Esophagitis, Peptic / complications* Female Food Hypersensitivity / complications* Humans Infant Infant Behavior* Infant Food Male Milk Hypersensitivity / complications Vomiting / etiology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dietary Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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