Document Detail


Role of fatty acid transporters in epidermis: Implications for health and disease.
MedLine Citation:
PMID:  21695012     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Skin epidermis is an active site of lipid synthesis. The intercellular lipids of human stratum corneum (SC) are unique in composition and quite different from the lipids found in most biological membranes. The three major lipids in the SC are free fatty acids, cholesterol and ceramides. Fatty acids can be synthesized by keratinocytes de novo and, in addition, need to be taken up from the circulation. The latter process has been shown to be protein mediated, and several fatty acid transporters are expressed in skin. Recent studies of transgenic and knockout animal models for fatty acid transporters and the identification of fatty acid transport protein 4 (FATP4 or SLC27A4) mutations as causative for Ichthyosis Prematurity Syndrome highlight the vital roles of fatty acid transport and metabolism in skin homeostasis. This review provides an overview of our current understanding of the role of fatty acids and their transporters in cutaneous biology, including their involvement in epidermal barrier generation and skin inflammation.
Authors:
Denis Khnykin; Jeffrey H Miner; Frode Jahnsen
Publication Detail:
Type:  Journal Article     Date:  2011-04-01
Journal Detail:
Title:  Dermato-endocrinology     Volume:  3     ISSN:  1938-1980     ISO Abbreviation:  Dermatoendocrinol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-06-22     Completed Date:  2011-07-14     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495367     Medline TA:  Dermatoendocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 AR049269/AR/NIAMS NIH HHS
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