| Role of factor XIII Val34Leu polymorphism in retinal artery occlusion. | |
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MedLine Citation:
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PMID: 11739969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Factor XIII (FXIII) Val34Leu, a common polymorphism in the gene for factor XIII, has been associated with a lower risk of stroke, myocardial infarction, and deep vein thrombosis. Ineffective fibrin cross-linking has been suggested to be causative. The aim of the present case-control study was to investigate the role of FXIII Val34Leu polymorphism in patients with retinal artery occlusion. METHODS: A total of 108 patients with retinal artery occlusion and 313 age- and sex-matched controls were genotyped for the FXIII Val34Leu polymorphism. Factor XIII Val34Leu genotypes were determined by use of allele-specific polymerase chain reaction. RESULTS: Homozygous Leu genotype was found significantly more often in control subjects than in patients with retinal artery occlusion (P=0.018), with an odds ratio of 0.22 (95% confidence interval 0.07 to 0.74). Distribution of the Val/Val and Val/Leu genotypes did not differ significantly between groups. CONCLUSIONS: Because prevalence of homozygous Leu genotype was significantly higher in controls, we conclude that the Leu/Leu genotype is associated with a protective effect against retinal artery occlusion. |
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Authors:
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M Weger; W Renner; O Stanger; O Schmut; H Deutschmann; T C Wascher; A Haas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 32 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-13 Completed Date: 2002-01-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2759-61 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Auenbruggerplatz 4, A-80365 Graz, Austria. martin.weger@kfunigraz.ac.at |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Aged Aged, 80 and over Alleles Amino Acid Substitution / genetics Case-Control Studies Factor XIII / genetics* Female Gene Frequency Genetic Testing Genotype Homozygote Humans Immunity, Innate / genetics Male Middle Aged Odds Ratio Polymerase Chain Reaction Polymorphism, Genetic* Prevalence Retinal Artery Occlusion / epidemiology, genetics* Retrospective Studies Risk Factors Sex Distribution |
| Chemical | |
Reg. No./Substance:
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9013-56-3/Factor XIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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