Document Detail


Role of factor XIII Val34Leu polymorphism in retinal artery occlusion.
MedLine Citation:
PMID:  11739969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Factor XIII (FXIII) Val34Leu, a common polymorphism in the gene for factor XIII, has been associated with a lower risk of stroke, myocardial infarction, and deep vein thrombosis. Ineffective fibrin cross-linking has been suggested to be causative. The aim of the present case-control study was to investigate the role of FXIII Val34Leu polymorphism in patients with retinal artery occlusion. METHODS: A total of 108 patients with retinal artery occlusion and 313 age- and sex-matched controls were genotyped for the FXIII Val34Leu polymorphism. Factor XIII Val34Leu genotypes were determined by use of allele-specific polymerase chain reaction. RESULTS: Homozygous Leu genotype was found significantly more often in control subjects than in patients with retinal artery occlusion (P=0.018), with an odds ratio of 0.22 (95% confidence interval 0.07 to 0.74). Distribution of the Val/Val and Val/Leu genotypes did not differ significantly between groups. CONCLUSIONS: Because prevalence of homozygous Leu genotype was significantly higher in controls, we conclude that the Leu/Leu genotype is associated with a protective effect against retinal artery occlusion.
Authors:
M Weger; W Renner; O Stanger; O Schmut; H Deutschmann; T C Wascher; A Haas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  32     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-13     Completed Date:  2002-01-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2759-61     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Auenbruggerplatz 4, A-80365 Graz, Austria. martin.weger@kfunigraz.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Aged
Aged, 80 and over
Alleles
Amino Acid Substitution / genetics
Case-Control Studies
Factor XIII / genetics*
Female
Gene Frequency
Genetic Testing
Genotype
Homozygote
Humans
Immunity, Innate / genetics
Male
Middle Aged
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic*
Prevalence
Retinal Artery Occlusion / epidemiology,  genetics*
Retrospective Studies
Risk Factors
Sex Distribution
Chemical
Reg. No./Substance:
9013-56-3/Factor XIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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