Document Detail

Role of extracellular volume expansion in the development of DOC-salt hypertension in the rat.
MedLine Citation:
PMID:  7106934     Owner:  NLM     Status:  MEDLINE    
Changes in inulin space, plasma and blood volume, exchangeable and "noninulin" sodium were studied during the prehypertensive, early and late hypertensive stages of deoxycorticosterone (DOC)-salt administration in the rat. The effect of an acute water load in previously nephrectomized animals was also studied. Hypertension developed after 1 to 2 weeks of the DOC-salt regimen and was always preceded by enlargement of the inulin space and increased plasma and blood volume. Expansion of extracellular fluids receded when blood pressure started to rise but reappeared after 4 to 6 weeks of treatment. Plasma sodium was high only in the hypertensive groups. An acute water load increased blood pressure of normal rats and decreased blood pressure of DOC-salt early hypertensive rats. These findings suggest that extracellular volume expansion inhibits a vasopressor mechanism that involves vasopressin and could be stimulated by hypernatremia.
M F Villamil; C Amorena; J Ponce-Hornos; A Müller; A C Taquini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  4     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1982 Sep-Oct
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  620-4     Citation Subset:  IM    
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MeSH Terms
Blood Volume
Extracellular Space*
Hypertension / chemically induced*,  physiopathology
Inulin / metabolism
Plasma Volume
Rats, Inbred Strains
Sodium Chloride*
Vasomotor System / physiopathology
Vasopressins / physiology
Reg. No./Substance:
11000-17-2/Vasopressins; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride; 7732-18-5/Water; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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