Document Detail

Role of extracellular adenosine triphosphate in human skin.
MedLine Citation:
PMID:  15129319     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The nucleotide adenosine triphosphate (ATP) has long been known to drive and participate in countless intracellular processes. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin. Knowledge of the sources and effects of extracellular ATP in human skin may help shape new therapies for skin injury, inflammation, and numerous other cutaneous disorders. OBJECTIVE: The objective of this review is to introduce the reader to current knowledge regarding the sources and effects of extracellular ATP in human skin and to outline areas in which further research is necessary to clarify the nature and mechanism of these effects. CONCLUSION: Extracellular ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity.
Aton M Holzer; Richard D Granstein
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Publication Detail:
Type:  Journal Article; Review     Date:  2004-05-03
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  8     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2004 Mar-Apr
Date Detail:
Created Date:  2005-02-01     Completed Date:  2005-03-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-6     Citation Subset:  IM    
Department of Dermatology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021, USA.
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MeSH Terms
Adenosine Triphosphate / metabolism,  physiology*
Extracellular Space / metabolism*
Skin / cytology,  metabolism
Skin Physiological Phenomena*
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

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