Document Detail

Role of exercise and metabolism in heart failure with normal ejection fraction.
MedLine Citation:
PMID:  17185114     Owner:  NLM     Status:  MEDLINE    
Left ventricular dysfunction associated with metabolic disorders has a number of features that might shed light on the integrity of heart failure with normal ejection fraction. First, although these patients may be dyspneic and have a normal ejection fraction, their diastolic dysfunction is not isolated. Both experimental models and sensitive new parameters in humans have shown abnormal systolic function, even though the less sensitive parameters (such as ejection fraction) become abnormal only with stress. Moreover, the mechanistic contributors to myocardial dysfunction, including structural changes and metabolic influences on the cardiac myocyte, interstitial fibrosis, vascular disease, and altered loading, are likely to influence systolic as much as diastolic function. The responses of systolic and diastolic heart failure to exercise training show analogies, particularly with respect to the importance of peripheral adaptation, as well as a similar training response. Together, these features are more supportive of a continuum of pathophysiology between systolic and diastolic heart failure, rather than the 2 representing discreet phenomena.
Thomas H Marwick; Chiew Y Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  49     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-74     Citation Subset:  AIM; IM    
Department of Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.
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MeSH Terms
Cardiac Output, Low / metabolism,  physiopathology*
Chronic Disease
Diabetes Complications / metabolism,  physiopathology
Exercise Tolerance*
Myocardial Contraction
Myocytes, Cardiac / metabolism*
Obesity / complications,  metabolism,  physiopathology
Risk Factors
Stroke Volume*
Ventricular Function, Left*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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