Document Detail

Role of excessive maternal iron in the pathogenesis of congenital leukoencephalomalacia in captive black rhinoceroses (Diceros bicornis).
MedLine Citation:
PMID:  11277198     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the possibility that excessive maternal iron (overload) may contribute to development of congenital leukoencephalomalacia in captive black rhinoceroses. SAMPLE POPULATION: Tissue specimens and serum samples from 18 rhinoceroses in 2 kindreds harboring 4 (possibly 5) affected female calves. PROCEDURE: Fresh and archival sera and necropsy tissue specimens were evaluated to determine the nature and extent of iron overload in captive and wild black rhinoceroses as well as other rhinoceros species. RESULTS: Quantitative serum and tissue assays of iron and iron analytes, corroborated by histopathologic findings, indicated that these kindreds carried the greatest body burdens of iron yet found among captive black rhinoceroses. Fourteen of 18 rhinoceroses had the highest serum ferritin concentrations measured among 64 black rhinoceroses in captivity in the United States. Dams of affected calves had serum ferritin concentrations 2 orders of magnitude higher than clinically normal humans, equids, or free-ranging rhinoceroses. A neonatal serum sample from 1 affected female calf had a high ferritin concentration (approx 100-fold increase), but a male sibling of another affected female did not, suggesting a possible sex disparity in fetal response to maternal iron overload. Morphologic hallmarks of hemochromatosis were prominent in dams and grandams of affected calves. CONCLUSIONS AND CLINICAL RELEVANCE: Excessive maternal iron may affect female fetuses more than males, possibly inducing leukoencephalomalacia by catalyzing production of highly toxic hydroxyl free radicals during crucial periods of in utero development. Reduction of maternal iron overload may decrease the probability of developing leukoencephalomalacia and some other disorders commonly affecting rhinoceroses in captivity.
D E Paglia; D E Kenny; E S Dierenfeld; I H Tsu
Related Documents :
8025358 - Minerals and trace elements in infant nutrition.
16080798 - Iron absorption and oxidant stress during erythropoietin therapy in very low birth weig...
4050728 - Does iron supplementation compromise zinc nutrition in healthy infants?
758728 - Breast milk iron--a declining concentration during the course of lactation.
3267818 - Heterogeneity of nemaline myopathy. a follow-up study of 13 cases.
263878 - Blood glucose and plasma amino acid concentrations in infants of diabetic mothers.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  62     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-9     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1732, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Encephalomalacia / congenital,  etiology,  genetics,  veterinary*
Ferritins / blood
Haptoglobins / metabolism
Histocytochemistry / veterinary
Iron / blood,  metabolism
Iron Overload / complications,  genetics,  pathology,  veterinary*
Liver / metabolism
Perissodactyla / blood,  genetics,  metabolism*
Pregnancy Complications / blood,  metabolism
Transferrin / metabolism
Reg. No./Substance:
0/Haptoglobins; 11096-37-0/Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative efficacy of tricaine methanesulfonate and clove oil for use as anesthetics in red pacu (...
Next Document:  Petrographic and geochemic evaluation of equine enteroliths.