| Role of ethnicity in overweight and obese subjects with nonalcoholic steatohepatitis (NASH). | |
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MedLine Citation:
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PMID: 21674556 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The role of ethnicity in determining disease severity in NASH remains unclear. To better understand this, we recruited 152 subjects with biopsy-proven NASH (Hispanics: 63%; Caucasians: 37%). Both groups were well matched for age, gender and total body fat. We measured: 1) liver fat (LFAT) by magnetic resonance imaging and spectroscopy (MRS); 2) fasting glucose, insulin (FPI) and free fatty acid (FFA) levels; 3) total body fat (TBF) by dual energy x-ray absorptiometry (DXA); 4) liver and muscle (Rd) insulin sensitivity (insulin clamp with 3-[(3) H] glucose); 5) insulin resistance at the level of the liver (fasting endogenous glucose production derived from 3-[(3) H] glucose infusion x FPI) and adipose tissue (fasting FFA x FPI). LFAT was slightly, but not significantly, higher in Hispanics vs. Caucasians (27±2% vs. 24±2%, p=0.16). However, this trend did not translate into worse liver histology (stetaosis, necroinflammation or fibrosis, all NS). Patients with NASH had severe hepatic, adipose tissue and muscle insulin resistance vs. subjects without NAFLD (p<0.01-p<0.0001), but there were no differences between both ethnic groups on these parameters. However, Hispanics vs. Caucasians with T2DM had a trend for worse hepatic/adipose tissue insulin resistance and fibrosis (p=0.052). CONCLUSION: when Hispanics and Caucasians with NASH are well matched for clinical parameters, in particular for adiposity, the slightly higher LFAT content is not associated with worse hepatic insulin resistance or more severe NASH on histology. Hispanic ethnicity does not appear to be a major determinant of disease severity in NASH, although those with diabetes may be at greater risk of fibrosis. Given the higher risk of T2DM in Hispanics, long-term studies are needed to define their risk of disease progression. (HEPATOLOGY 2011.). |
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Authors:
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Romina Lomonaco; Carolina Ortiz-Lopez; Beverly Orsak; Joan Finch; Amy Webb; Fernando Bril; Christopher Louden; Fermin Tio; Kenneth Cusi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-14 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: - ISSN: 1527-3350 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 American Association for the Study of Liver Diseases. |
Affiliation:
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Divisions of Diabetes, The University of Texas Health Science Center at San Antonio (UTHSCSA), Texas; Audie L. Murphy Veterans Administration Medical Center (VAMC), San Antonio, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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