| Role of ethamsylate in preventing periventricular-intraventricular hemorrhage in premature infants below 34 weeks of gestation. | |
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MedLine Citation:
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PMID: 10740301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the role of ethamsylate in prevention of PVH-IVH in premature infants <34 weeks gestational age. DESIGN: Prospective, randomized, controlled study. METHODS: Infants less than 34 weeks gestational age were included in the trial. Neonates with congenital malformations, family history of bleeding disorders and with Apgar scores <5 at 5 minutes were excluded. Subjects were randomized into two groups--Group A infants received intravenous ethamsylate (12.5 mg/kg) six hourly for four days and Group B infants served as a control group. Regular cranial ultrasounds to detect the presence of PVH-IVH were done between days 3-5, 10-14 and 28-30 of post natal age, and before hospital discharge in all infants and weekly in infants detected to have PVH-IVH on earlier scans. Various antenatal and postnatal factors known to affect the incidence of PVH-IVH were recorded. RESULTS: A total of 192 infants underwent the trial, 93 in Group A and 99 in Group B. Antenatal corticosteroids (1 or 2 doses) were administered to 32 ( 34.4%) and 36 (36.3%) women in Group A and Group B, respectively. None of the mothers received phenobarbitone, vitamin K or indomethacin antenatally and none of the infants received phenobarbitone, vitamin E or indomethacin postnatally during the study period. PVH-IVH was seen in 26 infants in Group A, of which Grade I IVH occurred in 9, Grade II in 14, Grade III in 2 and Grade IV in one infant. Twenty-nine infants had PVH-IVH in Group B of which 11 had Grade I, 15 Grade II and 3 Grade III. None of the differences were statistically significant. CONCLUSION: Postnatal administration of ethamsylate did not decrease the incidence of PVH-IVH in the study infants. |
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Authors:
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K P Sanghvi; R H Merchant; A Karnik; A Kulkarni |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Indian pediatrics Volume: 36 ISSN: 0019-6061 ISO Abbreviation: Indian Pediatr Publication Date: 1999 Jul |
Date Detail:
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Created Date: 2001-01-05 Completed Date: 2001-01-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: INDIA |
Other Details:
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Languages: eng Pagination: 653-8 Citation Subset: IM |
Affiliation:
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Nowrosjee Wadia Maternity Hospital, Acharya Donde Marg, Parel, Mumbai 400 012, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Hemorrhage
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prevention & control* Cerebral Ventricles* Ethamsylate / therapeutic use* Female Gestational Age Hemostatics / therapeutic use* Humans Infant, Newborn Infant, Premature Male |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics; 2624-44-4/Ethamsylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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