Document Detail

Role of estradiol in puerperal psychosis.
MedLine Citation:
PMID:  10591876     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Postpartum period has been considered a time of increased risk for the development of psychiatric disorders with long-lasting adverse consequences. Psychoses are the most severe of these illnesses and can be resistant to psychiatric medication. OBJECTIVE: We present two women with puerperal psychosis who had low serum estradiol, were refractory to neuroleptic medication but responded successfully to estradiol treatment. METHODS: Serum estradiol concentration was measured at baseline and during the treatment with sublingual 17-beta estradiol. Treatment effect was evaluated using Brief Psychiatric Rating Scale. RESULTS: Both patients had a low pretreatment estradiol concentration (28 and 54 pmol/l). During treatment with estradiol, the rise in serum estradiol coincided with a decline of psychotic symptoms. Discontinuation of estradiol treatment resulted in a rebound of florid psychotic symptoms in both cases. CONCLUSIONS: Estradiol may have a causal relation to postpartum psychosis and significance in the treatment of this illness.
A Ahokas; M Aito
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  147     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  108-10     Citation Subset:  IM    
Department of Psychiatry, Helsinki City Hospital, Finland.
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MeSH Terms
Administration, Sublingual
Depression, Postpartum / drug therapy*,  psychology
Estradiol / administration & dosage,  blood,  physiology*,  therapeutic use*
Estrogens / deficiency
Progesterone / blood
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Estrogens; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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