Document Detail


Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis.
MedLine Citation:
PMID:  16084405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed.
Authors:
Brad W Warner; Barbara B Warner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in pediatric surgery     Volume:  14     ISSN:  1055-8586     ISO Abbreviation:  Semin. Pediatr. Surg.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-08     Completed Date:  2005-12-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9216162     Medline TA:  Semin Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Affiliation:
Division of Pediatric and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA. Brad.Warner@cchmc.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Enterocolitis, Necrotizing / etiology,  physiopathology*
Epidermal Growth Factor / pharmacology,  physiology*
Humans
Infant, Newborn
Infant, Premature / physiology
Intestines / drug effects*,  physiology*,  physiopathology
Models, Animal
Organogenesis / physiology*
Regeneration / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
R03 DK 61596/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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