| Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis. | |
| | |
MedLine Citation:
|
PMID: 16084405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed. |
| | |
Authors:
|
Brad W Warner; Barbara B Warner |
Related Documents
:
|
7175655 - Necrotizing enterocolitis in the unfed infant. 2861265 - Clostridial necrotizing enterocolitis. 4011145 - Effects of cyclopentolate eyedrops on gastric secretory function in pre-term infants. 12891835 - Current controversies in the understanding of necrotizing enterocolitis. part 1. 9402295 - Reproductive impact of congenital müllerian anomalies. 12777585 - Perinatal outcomes in two dissimilar immigrant populations in the united states: a dual... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Seminars in pediatric surgery Volume: 14 ISSN: 1055-8586 ISO Abbreviation: Semin. Pediatr. Surg. Publication Date: 2005 Aug |
Date Detail:
|
Created Date: 2005-08-08 Completed Date: 2005-12-13 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9216162 Medline TA: Semin Pediatr Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 175-80 Citation Subset: IM |
Affiliation:
|
Division of Pediatric and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA. Brad.Warner@cchmc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Enterocolitis, Necrotizing / etiology, physiopathology* Epidermal Growth Factor / pharmacology, physiology* Humans Infant, Newborn Infant, Premature / physiology Intestines / drug effects*, physiology*, physiopathology Models, Animal Organogenesis / physiology* Regeneration / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
R03 DK 61596/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
62229-50-9/Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis.
Next Document: Surgical therapy for necrotizing enterocolitis: bringing evidence to the bedside.