| Role of environmental stress in the physiological response to chemical toxicants. | |
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MedLine Citation:
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PMID: 12706749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Environmental physiology is the study of the physiological mechanisms that allow animals to cope with and adapt to changes in temperature, humidity, atmospheric pressure, and other natural factors of their physical environment. Nearly all toxicological and pharmacological studies are performed in resting (i.e., nonexercising) experimental animals acclimatized to standard environmental conditions that are usually considered ideal to the animal's physiological well-being. These ideal test conditions are clearly not representative of the fluctuations in the natural environment encountered by humans and other animals on a day-to-day basis. It behooves the toxicologist, especially those interested in extrapolating experimental data from laboratory animals to humans, to consider how variations in the natural environment will alter physiological responses to toxicants. Temperature and exercise are the two most well-studied parameters in the fields of environmental physiology and toxicology. In general, high temperatures exacerbate the toxic effects of many environmental toxicants. Moreover, exercising subjects are generally more vulnerable to airborne toxic agents. The prospect of global warming also warrants a better assessment of how higher environmental temperatures may impact on the response of humans and other species to toxic chemicals. Hence, this paper and accompanying papers from the proceedings of a symposium focus on the salient aspects of the interaction between environmental stress and physiological response to toxic agents with particular emphasis on temperature and exercise. |
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Authors:
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Christopher J Gordon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Environmental research Volume: 92 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-22 Completed Date: 2003-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. gordon.christopher@epa.gov <gordon.christopher@epa.gov> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Atmospheric Pressure Environment Environmental Pollutants / toxicity* Heat Stress Disorders* Humans Humidity Mortality / trends Xenobiotics / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Xenobiotics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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