Document Detail


Role of the enteric nervous system in the pathophysiology of secretory diarrhea.
MedLine Citation:
PMID:  12041649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Details of the physiology and pathophysiology of epithelial secretion in the gastrointestinal tract are becoming clear, leading to new models of the mechanisms underlying diarrhea. The enteric nervous system is a critical component of the mechanism regulating fluid secretion in the normal gut and a key element in the pathophysiology of diarrhea. Neural reflex pathways increase epithelial fluid secretion in response to several enteric pathogens of veterinary importance such as Salmonella spp., Cryptosporidium parvum, rotavirus, and Clostridium difficile. Moreover, the enteric nervous system has an important role in epithelial secretion triggered by products of activated leukocytes during inflammation. New approaches targeting the enteric nervous system show promise for the treatment of secretory diarrhea.
Authors:
Samuel L Jones; Anthony T Blikslager
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  16     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-03     Completed Date:  2002-11-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, USA. sam_jones@ncsu.edu
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MeSH Terms
Descriptor/Qualifier:
Animal Diseases / immunology,  physiopathology*
Animals
Bacterial Toxins / adverse effects*
Cryptosporidiosis / immunology,  physiopathology*
Diarrhea / physiopathology,  veterinary*
Enteric Nervous System / physiology*
Enterocolitis, Pseudomembranous / immunology,  physiopathology*
Inflammation
Salmonella Infections / immunology,  physiopathology*
Water-Electrolyte Balance / physiology
Chemical
Reg. No./Substance:
0/Bacterial Toxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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