Document Detail

Role of enhanced MRI in the follow-up of patients with medically refractory trigeminal neuralgia undergoing stereotactic radiosurgery using the gamma knife: initial experience.
MedLine Citation:
PMID:  11584232     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this work was to evaluate the early posttreatment MR findings, and their clinical utility, in patients with trigeminal neuralgia undergoing stereotactic radiosurgery using the gamma knife. METHOD: Twenty-six patients with medically refractory trigeminal neuralgia underwent stereotactic radiosurgery. A single dose of 70-90 Gy was administered to the proximal root entry zone (n = 21) or the retrogasserian portion (n = 5) of the trigeminal nerve. Posttreatment enhanced MRI and clinical assessment were performed at 3-6 months. RESULTS: Five patients did not have radiologic follow-up. There were no changes identified in the treated trigeminal nerve or adjacent brainstem in 19 of 21 patients. Two patients with multiple sclerosis developed abnormal signal and enhancement in the brainstem and/or trigeminal nerve; neither had clinical complications. Onset of therapeutic effect ranged from 3 weeks to 3 months; 19 patients had a beneficial response. CONCLUSION: Results of enhanced MRI 3-6 months after stereotactic radiosurgical treatment of trigeminal neuralgia do not correlate with the clinical response. Because beneficial clinical responses or treatment failures are apparent by 3 months, routine posttreatment MRI in these patients is not warranted.
D P Friedman; R E Morales; H W Goldman
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  25     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-10-03     Completed Date:  2001-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  727-32     Citation Subset:  IM    
Department of Radiology, Neurosensory Institute, Wills Eye Hospital, Philadelphia, PA, USA.
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MeSH Terms
Aged, 80 and over
Magnetic Resonance Imaging
Middle Aged
Regression Analysis
Sensitivity and Specificity
Treatment Outcome
Trigeminal Neuralgia / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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