Document Detail

Role of energy metabolism in retinal pigment epithelium.
MedLine Citation:
PMID:  23319062     Owner:  NLM     Status:  Publisher    
The universal energy source adenosine triphosphate (ATP)is reduced by approximately 30 % in the retinal pigment epithelium (RPE) of elderly persons. Increased oxidative stress and decreased antioxidative capacity, such as glutathione in aging eyes cause impairment of energy-dependent RPE processes and lead to loss of visual function. We developed a cell culture model of aging RPE using atractyloside to inhibit mitochondrial ATP synthesis and tert-butyl hydroperoxide as oxidant. The ATP levels were reduced by 30 % and oxidative damaged proteins and DNA increased whereas antioxidative glutathione decreased. Autophagy as an internal cellular repair mechanism and phagocytosis of photoreceptors were impaired. Antioxidative and mitochondria-activating Ginkgo biloba extract EGb 761® increased the intracellular ATP level and antioxidative glutathione. This cell culture model seems to be suitable to investigate in vitro the effect of protective substances and their compounds on aging processes in RPE.
F Schütt; S Aretz; G U Auffahrt; J Kopitz
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft     Volume:  -     ISSN:  1433-0423     ISO Abbreviation:  Ophthalmologe     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206148     Medline TA:  Ophthalmologe     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Augenklinik, Universität Heidelberg, INF 400, 69120, Heidelberg, Deutschland,
Vernacular Title:
Rolle des Energiestoffwechsels im retinalen Pigmentepithel.
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