Document Detail

Role of energy metabolism in the pregnancy interceptive action of Ferula assafoetida and Melia azedarach extracts in rat.
MedLine Citation:
PMID:  15504384     Owner:  NLM     Status:  MEDLINE    
Ethanolic extract of Ferula assafoetida and chloroform fraction of Melia azedarach, both devoid of estrogenic activity, were examined for their pregnancy interceptive property. Treatment of rats from days 1 to 7 of pregnancy with either of the plant extracts resulted in pregnancy failure in about 65-85% of the animals. The possible role of energy metabolism in the antifertility action was investigated by measuring changes in activities of the key enzymes of carbohydrate metabolism in uterus on day 7 of pregnancy. It was observed that on the day 7 of pregnancy, one key enzyme of glycolytic pathway (phosphofructokinase) was significantly reduced in the uteri of treated rats as compared to controls. Hexosemonophosphate pathway also appeared to be sensitive to treatment with the plant extracts and showed an inhibitory effect on the enzyme activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Oxidative energy metabolism through tricarboxylic acid cycle, which is considered to be the main source of energy to the uterus at this stage, was maximally affected by the treatment with several enzymes showing significant inhibition. The two plant materials appeared to interrupt the latter metabolic pathway more significantly. It is thus concluded that plants lacking phytoestrogens may intercept pregnancy by their ability to disrupt energy metabolism in rat uterus during implantation, especially the oxidative pathway.
Govind Keshri; Malini Bajpai; Vijai Lakshmi; Bachu Sreenivasulu Setty; Gopal Gupta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contraception     Volume:  70     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-26     Completed Date:  2005-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Division of Endocrinology, Central Drug Research Institute, P.O. Box 173 Mahatma Gandhi Marg, Lucknow-226001, India.
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MeSH Terms
Contraceptives, Oral / pharmacology*
Contraceptives, Postcoital / pharmacology*
Embryo, Mammalian / drug effects,  metabolism
Melia azedarach*
Plant Extracts / pharmacology*
Rats, Sprague-Dawley
Uterus / drug effects*,  metabolism
Reg. No./Substance:
0/Contraceptives, Oral; 0/Contraceptives, Postcoital; 0/Plant Extracts

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