| Role of endothelium and nitric oxide in experimental hypertension. | |
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MedLine Citation:
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PMID: 10805399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A short review on the role of endothelium and nitric oxide (NO) in experimental hypertension is presented in the light of the literature and our own recent findings. Based on these data, it is concluded that even though there is a lot of evidence in favor of the primary and causal association of endothelial dysfunction and NO in experimental hypertension, it seems still more plausible that they are causative in some types of hypertension only. Our own experience rather speaks for a secondary but still an important participation of endothelium in the maintenance and further elevation of high blood pressure. Endothelium plays a key role in the development of organ damages in hypertension. |
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Authors:
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H Vapaatalo; E Mervaala; M L Nurminen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 49 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2000 |
Date Detail:
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Created Date: 2000-06-30 Completed Date: 2000-06-30 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland. hvapaata@penger.helsinki.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / therapeutic use Diet Endothelium, Vascular / physiopathology* Hemodynamics Hypertension / etiology*, physiopathology, therapy Nitric Oxide / physiology* Rats Rats, Inbred SHR |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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