Document Detail


Role of endothelium-derived nitric oxide in the regulation of blood pressure.
MedLine Citation:
PMID:  2497467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of endothelium-derived nitric oxide in the regulation of blood pressure in the anesthetized rabbit was studied with N omega-monomethyl-L-arginine (L-NMMA), a specific inhibitor of its formation from L-arginine. L-NMMA (3-100 mg.kg-1), but not its D-enantiomer, induced a dose-dependent long-lasting (15-90 min) increase in mean systemic arterial blood pressure. L-NMMA (100 mg.kg-1) also inhibited significantly the hypotensive action of acetylcholine, without affecting that of glyceryl trinitrate. Both these actions of L-NMMA were reversed by L-arginine (300 mg.kg-1), but not by D-arginine (300 mg.kg-1), indomethacin (1 mg.kg-1), prazosin (0.3 mg.kg-1), or by vagotomy. The effects of L-NMMA in vivo were associated with a significant inhibition of the release of nitric oxide from perfused aortic segments ex vivo. This inhibition was reversed by infusing L-arginine through the aortic segments. These results indicate that nitric oxide formation from L-arginine by the vascular endothelium plays a role in the regulation of blood pressure and in the hypotensive actions of acetylcholine.
Authors:
D D Rees; R M Palmer; S Moncada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-09     Completed Date:  1989-06-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3375-8     Citation Subset:  IM    
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Arginine / analogs & derivatives,  pharmacology
Blood Pressure* / drug effects
Dose-Response Relationship, Drug
Endothelium, Vascular / physiology*
Indomethacin / pharmacology
Kinetics
Male
Nitric Oxide / metabolism*
Nitroglycerin / pharmacology
Phenylephrine / pharmacology
Prazosin / pharmacology
Rabbits
Stereoisomerism
Vagotomy
omega-N-Methylarginine
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 19216-56-9/Prazosin; 51-84-3/Acetylcholine; 53-86-1/Indomethacin; 55-63-0/Nitroglycerin; 59-42-7/Phenylephrine; 74-79-3/Arginine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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