| Role of endothelin-1 in renal regulation of acid-base equilibrium in acidotic humans. | |
| | |
MedLine Citation:
|
PMID: 22859405 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Endothelin-1 inhibits collecting duct sodium reabsorption and stimulates proximal and distal tubule acidification in experimental animals both directly and indirectly via increased mineralocorticoid activity. Dietary-induced acid loads were shown to increase renal endothelin-1 activity and it is hypothesized that increased dietary acid-induced endothelin-1 activity may be a causative progression factor in human renal insufficiency and that this might be reversed by provision of dietary alkali Aims: To clarify, in normal human volunteers, the role of endothelin-1 in renal acidification and to determine whether the effect is dependent on dietary sodium chloride. Methods: Acid-base equilibrium was studied 7 normal human volunteers with experimentally induced metabolic acidosis (NH(4)Cl 2.1 mmols/kg/bw/d) with and without inhibition of endogenous endothelin-1 activity by the endothelin A/B-receptor antagonist bosentan (125 bid p.o./d) both during dietary NaCl restriction (20 mmols/day) and NaCl repletion (2 mmols NaCl/kg bw/d). Results: During NaCl restriction, but not in the NaCl replete state, bosentan significantly increased renal net acid excretion in association with stimulation of ammoniagenesis resulting in a significantly increased plasma bicarbonate concentration (19.0±0.8 to 20.1± 0.9 mmol/L) despite a decrease in mineralocorticoid activity and an increase in endogenous acid production. Conclusions: In pre-existing human metabolic acidosis, endothelin-1 activity worsens acidosis by decreasing the set-point for renal regulation of plasma bicarbonate concentration, but only when dietary NaCl provision is restricted.. |
| | |
Authors:
|
Alexandra Pallini; Henry Nicolas Hulter; Jurgen Muser; Reto Krapf |
Related Documents
:
|
1332415 - Reactive formation of hyaluronic acid after small and large lens injury. 89615 - Detection of dna in mammalian tissues following removal of rna with cold phosphoric acid. 3728825 - Hyaluronic acid reduces connective tissue formation in middle ears filled with absorbab... 2448495 - Improved thiéry staining for the ultrastructural detection of polysaccharides. 9508445 - Ubiquinone synthesis by pneumocystis carinii: incorporation of radiolabeled polyprenyl ... 3342925 - Early effects of oestrogen treatment on lipogenesis de novo and on biosynthesis of tria... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-1 |
Journal Detail:
|
Title: American journal of physiology. Renal physiology Volume: - ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Kantonsspital Bruderholz. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: P2X7 deficiency attenuates hypertension and renal injury in deoxycorticosterone acetate (DOCA)-salt ...
Next Document: Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth ...