Document Detail

Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease.
MedLine Citation:
PMID:  21350026     Owner:  NLM     Status:  MEDLINE    
In clinical trials as well as in several animal experiments it is evident that physical exercise is a powerful tool to positively influence the development and/or progression of atherosclerosis and coronary artery disease (CAD). The main target of physical exercise seems to be the maintenance of an intact endothelial cell layer. Since the discovery that endothelial progenitor cells (EPCs) are present in the circulation and the knowledge that exercise, either as a single exercise bout or an exercise training program, have the potency to mobilize EPCs from the bone marrow, the contribution of the EPCs for the preservation or repair of the endothelial cell layer is still under debate. Either the EPCs differentiate into mature endothelial cells, or they stimulate via a paracrine mechanism mature endothelial cells to proliferate. It is still unclear, if the exercise-induced mobilization of EPCs is casually related to the improvement of endothelial function. This review will discuss the role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease.
Karsten Lenk; Madlen Uhlemann; Gerhard Schuler; Volker Adams
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-02-24
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  111     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2013-07-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM    
University Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany.
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MeSH Terms
Atherosclerosis / metabolism,  pathology,  physiopathology,  prevention & control*
Cell Differentiation
Cell Movement
Cell Proliferation
Coronary Artery Disease / metabolism,  pathology,  physiopathology,  prevention & control*
Endothelial Cells / metabolism,  pathology*
Paracrine Communication
Signal Transduction
Stem Cells / metabolism,  pathology*

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