Document Detail


Role of endothelial-mesenchymal transition in idiopathic portal hypertension.
MedLine Citation:
PMID:  23275299     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Idiopathic portal hypertension (IPH) is a condition of non-cirrhotic portal hypertension without a known cause of liver disease. Obliterative portal venopathy is regarded as the primary lesion, which is responsible for the pre-sinusoidal block of hepatic blood flow leading to the development of IPH. The disease pathogenesis of IPH seems to be heterogeneous, and the pathogenic mechanisms of obliterative portal venopathy have not been fully understood. Owing to the limited understanding of the disease pathogenesis, the treatment of IPH is still largely supportive. Recently, endothelial dysfunction has been documented during the development of portal hypertension, and its contribution to IPH is being analyzed. Endothelial-mesenchymal transition (EndMT) is a phenomenon whereby vascular endothelial cells acquire myofibroblastic features characterized by an ability to express mesenchymal cell products that are related to tissue fibrogenesis. In addition to cardiovascular development, there is increasing evidence showing that EndMT is likely to be involved in a variety of fibrotic diseases, such as cardiac, pulmonary, and renal fibrosis. This article reviews the recent progress in studies of the pathogenic mechanisms of IPH in terms of endothelial dysfunction of portal veins. In particular, the role of EndMT in obliterative portal venopathy of IPH is highlighted and discussed.
Authors:
Y Sato; Y Nakanuma
Related Documents :
23840939 - Vascular adhesion protein 1 in the eye.
21524789 - Influence of surface roughness on streptococcal adhesion forces to composite resins.
21484289 - Efficacy of denture adhesives in maxillary dentures using gnathodynamometry: a comparat...
22391529 - L-selectin and p-selectin are novel biomarkers of cervicovaginal inflammation for precl...
22277619 - Assessment of bactericidal effects of quaternary ammonium-based antibacterial monomers ...
6882509 - Influence of fibrin, fibrinogen and fibrinogen degradation products on cultured endothe...
23319049 - Fosl1 controls the assembly of endothelial cells into capillary tubes by direct repress...
1592359 - Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cell...
15940769 - Vasculitis and expression of vascular cell adhesion molecule-1, intercellular adhesion ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  28     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  145-54     Citation Subset:  IM    
Affiliation:
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genome-wide association study of cardiac structure and systolic function in African Americans: the C...
Next Document:  Physical forces and non linear dynamics mould fractal cell shape. Quantitative morphological paramet...