Document Detail

Role of endothelial function and inflammation in patients with cardiovascular risk factors, with and without a history of myocardial infarction.
MedLine Citation:
PMID:  16735792     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelial dysfunction and inflammation, in particular their lack of improvement after risk reduction, might better reflect advanced atherosclerosis than just the presence of risk factors. The aim of this study was to compare endothelial function and inflammatory parameters in high-risk patients who had no history of myocardial infarction and in patients in a stable phase after myocardial infarction. METHODS: We compared endothelial function of the brachial artery, measured using high-resolution ultrasound, in 45 patients with hyperlipidaemia (Group 1), and in 45 patients in a stable period after myocardial infarction (Group 2). Forty-five healthy individuals served as a control group (Group 3). RESULTS: Compared to patients with treated hyperlipidaemia, patients after myocardial infarction had lower values of total and LDL cholesterol (p = 0.015; 0.005) and homocysteine (p < 0.005), but marginally higher IL-6 levels (p = 0.1). Other measurements were comparable. However, flow-mediated dilation of the brachial artery was significantly diminished in patients after myocardial infarction (10.6 +/- 3.0; 5.9 +/- 4.0; 14.0 +/- 1.9% for Groups 1-3; ANOVA p = 0.0001; respectively). CONCLUSIONS: We found that patients with previous myocardial infarction have substantially lower endothelial function and increased some inflammatory parameters than patients with a similar level of atherosclerotic risk profile but without clinically evident coronary artery disease.
Miran Sebestjen; Miso Sabovic; Barbara Erzen; Sasa Simcic; Branka Zegura; Pavel Poredos; Irena Keber
Publication Detail:
Type:  Journal Article     Date:  2006-05-24
Journal Detail:
Title:  Cardiology     Volume:  107     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2007  
Date Detail:
Created Date:  2006-12-21     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Angiology, University Clinical Centre, Hospital of Internal Medicine, Ljubljana, Slovenia.
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MeSH Terms
Analysis of Variance
Blood Flow Velocity
Brachial Artery / physiopathology,  ultrasonography
Cardiovascular Diseases / etiology*,  physiopathology
Cholesterol / blood
Endothelium, Vascular / physiopathology*
Homocysteine / blood
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hyperlipidemias / drug therapy,  physiopathology
Inflammation / physiopathology,  ultrasonography
Middle Aged
Myocardial Infarction / physiopathology*
Risk Factors
Statistics, Nonparametric
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 454-28-4/Homocysteine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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