| Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses. | |
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MedLine Citation:
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PMID: 21030518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic airway infection and inflammation are hallmarks of cystic fibrosis (CF) pulmonary disease. The altered airway environment resulting from infection and inflammation can affect the innate defense of the airway epithelia. Luminal bacterial and inflammatory stimuli trigger an adaptation in human airway epithelia, characterized by a hyperinflammatory response to inflammatory mediators, which is mediated by an expansion of the endoplasmic reticulum (ER) and its Ca(2+) stores. Recent studies demonstrated that a form of ER stress, the unfolded protein response (UPR), is activated in airway epithelia by bacterial infection-induced airway inflammation. UPR-dependent signaling is responsible for the ER Ca(2+) store expansion-mediated amplification of airway inflammatory responses. These studies highlight the functional importance of the UPR in airway inflammation and suggest that targeting the UPR may be a therapeutic strategy for airway diseases typified by chronic inflammation. This article reviews the contribution of airway epithelia to airway inflammatory responses, discusses how expansion of the ER Ca(2+) stores in inflamed airway epithelia contributes to airway inflammation, describes the functional role of the UPR in these processes, and discusses how UPR activation might be relevant for CF airways inflammatory disease. |
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Authors:
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Carla M P Ribeiro; Richard C Boucher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Proceedings of the American Thoracic Society Volume: 7 ISSN: 1943-5665 ISO Abbreviation: Proc Am Thorac Soc Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-03-17 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 101203596 Medline TA: Proc Am Thorac Soc Country: United States |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: IM |
Affiliation:
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Cystic Fibrosis/Pulmonary Research and Treatment Center and the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. carla_ribeiro@med.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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metabolism* Cystic Fibrosis / metabolism, physiopathology* Endoplasmic Reticulum / metabolism* Humans Inflammation / metabolism* Signal Transduction Unfolded Protein Response |
| Grant Support | |
ID/Acronym/Agency:
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HL34322/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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