| Role of endogenous platelet-activating factor in the regulation of pancreatic blood flow during caerulein stimulation. | |
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MedLine Citation:
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PMID: 8726834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of endogenous platelet-activating factor (PAF) in the control of pancreatic blood flow during caerulein stimulation was investigated. Pancreatic blood flow in anesthetized rats was measured continuously by laser Doppler flowmetry for 2 h during the intravenous infusion of caerulein (0.25 micrograms/kg per h). Pancreatic blood flow showed a gradual, consistent, and significant increase, reaching 114.2 +/- 2.3% of the basal value after 120 min. Changes in pancreatic blood flow induced by caerulein were completely inhibited by a cholecystokinin (CCK) antagonist (loxiglumide, 5 mg/ kg per h, i.v.) and by a specific PAF antagonist (CV-6209, 1 mg/kg, i.v.-bolus). Systemic blood pressure remained stable in all groups. These results suggest an important role of endogenously yielded PAF in regulating pancreatic blood flow during caerulein stimulation to the pancreas. |
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Authors:
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M Ogura; Y Kubota; K Inoue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology Volume: 31 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-10-23 Completed Date: 1996-10-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 414-9 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caerulein / pharmacology* Cholecystokinin / antagonists & inhibitors Gastrointestinal Agents / pharmacology* Hormone Antagonists / pharmacology Laser-Doppler Flowmetry Male Pancreas / blood supply* Platelet Activating Factor / antagonists & inhibitors, physiology* Proglumide / analogs & derivatives, pharmacology Pyridinium Compounds / pharmacology Rats Rats, Wistar Regional Blood Flow / drug effects Stimulation, Chemical Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 0/Hormone Antagonists; 0/Platelet Activating Factor; 0/Pyridinium Compounds; 100488-87-7/CV 6209; 107097-80-3/loxiglumide; 17650-98-5/Caerulein; 6620-60-6/Proglumide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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