| Role of endogenous opioids on nociceptive threshold in patients with exercise-induced myocardial ischemia. | |
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MedLine Citation:
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PMID: 1913714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate whether endogenous opioids (EO) play a role in the perception of anginal pain, a randomized double blind clinical trial, using naloxone (N) and placebo (P) and measuring beta-endorphin (beta-ep) plasma levels, was performed. We studied 10 patients with angiographically assessed coronary artery disease (CAD) and stable exercise-induced myocardial ischemia (established by 2 preliminary bicycle ergometric tests) of whom 5 symptomatic (SYM) and 5 asymptomatic (ASYM) and 5 subjects without CAD as a control group (CON). On a third exercise test the beta-ep plasma level (fmol/ml) was measured at rest (SYM 5.4 +/- 2.3 vs ASYM 7.2 +/- 2.3 vs CON 6.8 +/- 2.6, NS), at peak exercise (SYM 4.4 +/- 1.8 vs ASYM 8.0 +/- 4.2 and vs CON 6.2 +/- 2.7, NS) and during recovery (SYM 7.5 +/- 4.2 vs ASYM 7.2 +/- 3.0 vs CON 6.7 +/- 2.5, NS). On 2 subsequent tests patients received N (0.2 mg/kg) or P intravenously and chest pain was evaluated on an analogue scale (score from 1 to 10). After N compared to P we observed: an increased perception of chest pain in SYM (6.8 +/- 1.5 vs 4.2 +/- 1.0; p less than 0.01) without significant changes of the ischemic threshold (total work, heart rate-blood pressure product, ST segment changes, 2D-echocardiographic wall motion abnormalities); no modifications in ASYM and CON.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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F Fedele; G Benedetti; C D Vizza; L Agati; M Penco; C Barletta; D Scavo; A Dagianti |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cardiologia (Rome, Italy) Volume: 36 ISSN: 0393-1978 ISO Abbreviation: Cardiologia Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-11-13 Completed Date: 1991-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8506637 Medline TA: Cardiologia Country: ITALY |
Other Details:
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Languages: eng Pagination: 207-11 Citation Subset: IM |
Affiliation:
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Fisiopatologia Cardiovascolare, Università degli Studi, L'Aquila, Roma. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Disease / physiopathology* Double-Blind Method Exercise Test Female Humans Male Middle Aged Naloxone / diagnostic use Pain Measurement* beta-Endorphin / blood, physiology* |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 60617-12-1/beta-Endorphin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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