Document Detail

Role for the endogenous natriuretic peptide system in the control of basal coronary vascular tone in dogs.
MedLine Citation:
PMID:  8665772     Owner:  NLM     Status:  MEDLINE    
1. While the natriuretic peptides (atrial, brain and C-type) mediate potent endothelium-independent vasorelaxing actions in vitro, the role of the endogenous natriuretic peptide system in vascular regulation in vivo remains unclear. 2. HS-142-1 is a novel natriuretic peptide receptor antagonist derived from a fungus named Aureobasidium sp. which selectively blocks particulate guanylate cyclase-linked natriuretic peptide A and B receptors that bind atrial, brain and C-type natriuretic peptide, and thus attenuates the generation of cGMP. 3. To characterize the vascular actions of the endogenous natriuretic peptide system in the control of basal coronary and systemic haemodynamics, six normal male mongrel anaesthetized dogs were studied while a second group of five dogs served as a control. HS-142-1 was given as an intravenous bolus at 3 mg/kg and was studied over five 20 min periods. 4. No significant difference after HS-142-1 was observed in mean arterial pressure, heart rate, cardiac output, right atrial pressure, pulmonary capillary wedge pressure or systemic vascular resistance compared with control. In contrast, a significant increase in coronary vascular resistance and decrease in coronary blood flow were observed which were different from the baseline values and the responses of the control group. 5. These studies demonstrate that HS-142-1 produces vasoconstriction in the coronary circulation. We conclude that the endogenous natriuretic peptide system, which is of cardiac and endothelial cell origin, is an important regulator of basal coronary vascular tone.
T Supaporn; P W Wennberg; C M Wei; M Kinoshita; Y Matsuda; J C Burnett
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  90     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-08-08     Completed Date:  1996-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Cardiorenal Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Atrial Natriuretic Factor / antagonists & inhibitors,  blood,  physiology*
Coronary Circulation / physiology*
Cyclic GMP / blood
Polysaccharides / pharmacology
Vascular Resistance / physiology*
Vasoconstriction / physiology
Grant Support
Reg. No./Substance:
0/HS 142-1; 0/Polysaccharides; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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