| Role of endogenous angiotensin II and prostaglandins in the antihypertensive mechanism of angiotensin converting enzyme inhibitor in hypertension. | |
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MedLine Citation:
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PMID: 3038419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of endogenous angiotensin II and prostaglandins (PGs) in the antihypertensive effect of converting enzyme inhibitor, captopril, was studied in essential hypertension by the separate and the combined administration of captopril and indomethacin. Although plasma angiotensin II was similarly suppressed by the separate and the combined administration of captopril and indomethacin, captopril lowered and indomethacin increased the mean blood pressure. There were negative correlations between the changes in mean blood pressure and in urinary sodium excretion as well as in urinary PGE excretion. These results suggest that endogenous PGs may be implicated in the antihypertensive effect of captopril through the alteration of sodium balance. |
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Authors:
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K Omata; K Abe; K Tsunoda; M Yasujima; S Chiba; M Sato; K Kudo; K Yoshinaga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension. Part A, Theory and practice Volume: 9 ISSN: 0730-0077 ISO Abbreviation: Clin Exp Hypertens A Publication Date: 1987 |
Date Detail:
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Created Date: 1987-08-28 Completed Date: 1987-08-28 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 8207790 Medline TA: Clin Exp Hypertens A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 569-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II / physiology* Angiotensin-Converting Enzyme Inhibitors* Blood Pressure / drug effects Captopril / therapeutic use* Diet, Sodium-Restricted Female Humans Hypertension / diet therapy, drug therapy* Indomethacin / pharmacology Male Prostaglandins / physiology* Sodium / urine Thromboxane B2 / urine |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Prostaglandins; 11128-99-7/Angiotensin II; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 62571-86-2/Captopril; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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