Document Detail


Role of electrophysiologic testing in the therapy of ventricular arrhythmias.
MedLine Citation:
PMID:  6195628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The past decade has witnessed important advances in the understanding of the mechanism underlying ventricular arrhythmias. It has become clear that sustained ventricular arrhythmias can generally be reproduced with programmed ventricular stimulation in the clinical electrophysiology laboratory. False positive results may, however, occur with very vigorous stimulation techniques, particularly in patients without documented arrhythmias. False negative results are not infrequent in victims of cardiac arrest. Ability or inability to initiate ventricular tachycardia during acute and chronic drug testing has predicted clinical failure or success, at least for conventional antiarrhythmics. Patients with sustained ventricular tachycardia and cardiac arrest occurring outside the peri-infarction period are those most likely to benefit from study. Conventional antiarrhythmic agents are successful in about one-third of patients with a high degree of concordance among these drugs. Amiodarone is frequently effective in patients with drug-refractory ventricular arrhythmias. However, its efficacy cannot be predicted by programmed stimulation. This is in striking contrast to Type 1A anti-arrhythmic agents.
Authors:
J U Doherty; M E Josephson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  6     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1070-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Arrhythmia Agents / therapeutic use
Arrhythmias, Cardiac / diagnosis,  drug therapy*,  physiopathology
Cardiac Pacing, Artificial*
Electrocardiography*
Heart Arrest / complications
Heart Conduction System / drug effects
Heart Ventricles / physiopathology
Humans
Myocardial Infarction / complications
Prognosis
Grant Support
ID/Acronym/Agency:
HL00361/HL/NHLBI NIH HHS; HL07346/HL/NHLBI NIH HHS; HL24278/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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