Document Detail

Role of eicosanoids in relative oxygen tolerance of newborn rabbits.
MedLine Citation:
PMID:  2762558     Owner:  NLM     Status:  MEDLINE    
Prolonged exposure to hyperoxia can result in significant lung injury, although newborn animals are more oxygen-tolerant than adults. Mechanisms affording tolerance to the newborn are incompletely understood. This study examined the hypothesis that eicosanoids play a significant role in newborn oxygen tolerance. One litter of term newborn albino rabbits and 15 adult rabbits were exposed to 65 hours of greater than 95% O2. An additional litter of newborns served as a normoxic control. Normoxic newborn rabbits had very high quantities of 6-keto-PGF1a and low TXB2 in bronchoalveolar lavage (BAL) fluid. Sixty-five hours of oxygen exposure in newborn rabbits produced no evidence of lung injury on light microscopy, 97% of BAL white cells were alveolar macrophages and BAL protein was low. An equal period of oxygen exposure produced significant lung injury in adult rabbits. BAL fluid from oxygen-injured adults contained a 17-fold greater percentage of PMN and 16-fold higher protein than oxygen-exposed newborns. Hyperoxic adults had significantly lower 6-keto-PGF1a, and significantly higher LTB4 and LTC4 in BAL compared to hyperoxic newborns. This study confirms the hypothesis of relative oxygen tolerance in newborn rabbits compared to adults, and suggests that this tolerance may have been afforded by higher pulmonary levels of the protective prostacyclin metabolite.
R B Holtzman; J Zemaitis; L Adler; L J Smith; C E Hunt; J R Hageman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Prostaglandins     Volume:  37     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-09-20     Completed Date:  1989-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-91     Citation Subset:  IM    
Department of Pediatrics, Northwestern University Medical School, Evanston, Illinois 60201.
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MeSH Terms
Animals, Newborn
Arachidonate 5-Lipoxygenase / metabolism
Drug Tolerance
Leukotrienes / physiology*
Lung / drug effects,  pathology,  physiology*
Macrophages / physiology
Oxygen / pharmacology*,  toxicity
Prostaglandins / physiology*
Reference Values
Reg. No./Substance:
0/Leukotrienes; 0/Prostaglandins; 7782-44-7/Oxygen; EC 5-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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