| Role of eIF3a in regulating cell cycle progression. | |
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MedLine Citation:
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PMID: 19327350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators. |
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Authors:
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Zizheng Dong; Zhaoqian Liu; Ping Cui; Roxana Pincheira; Youyun Yang; Jianguo Liu; Jian-Ting Zhang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-24 |
Journal Detail:
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Title: Experimental cell research Volume: 315 ISSN: 1090-2422 ISO Abbreviation: Exp. Cell Res. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373226 Medline TA: Exp Cell Res Country: United States |
Other Details:
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Languages: eng Pagination: 1889-94 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, IU Simon Cancer Center, Walther Oncology Center/Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cell Cycle / genetics, physiology* Cell Line Cell Proliferation DNA Primers / genetics DNA, Antisense / genetics Down-Regulation Eukaryotic Initiation Factor-3 / antagonists & inhibitors, genetics, physiology* Gene Expression Humans Mice NIH 3T3 Cells Protein Biosynthesis RNA, Messenger / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA94961/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Antisense; 0/Eukaryotic Initiation Factor-3; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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