Document Detail


Role for dopamine-3 receptor in the hyperphagia of an unanticipated high-fat meal in rats.
MedLine Citation:
PMID:  16978686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioral studies have indicated that midbrain dopamine projections arising in the ventral tegmental area and substantia nigra play a central role in integrating violations of expectancy in reward-related paradigms. The present study was designed to assess violations of dietary expectation and the role the dopamine-3 receptor plays in integrating reward-related food intake in violations of expectancy. Two groups of rats were conditioned to a meal-feeding schedule (3 h of access to food per day) in which they received either standard rodent chow or a preferable, high-fat diet. Animals either received the diet they had access to during the training period (no contrast) or the opposite diet (negative and positive contrast). As predicted, animals in the positive contrast condition were hyperphagic compared to no contrast animals. Animals in the negative contrast (high fat to chow) condition were hypophagic compared to no contrast animals. A dopamine agonist specific to the dopamine three receptor, ((+/-)-7-Hydroxy-dipropylaminotetralin HBr) and the dopamine-2 receptor antagonist raclopride were administered in equimolar doses peripherally to assess the involvement of the dopamine receptor subtypes in the violation of expectancy food intake effects. 7-Hydroxy-dipropylaminotetralin HBr blocked the hyperphagia associated with positive contrast and did not disrupt intake in the negative contrast or no contrast paradigm. Raclopride was ineffective at disrupting food intake. These results support the hypothesis that the dopamine-3 receptor is involved in the hyperphagia of an unexpected high fat meal.
Authors:
Jon F Davis; John-Andrews M McQuade; Deborah L Drazen; Stephen C Woods; Randy J Seeley; Stephen C Benoit
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-09-14
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  85     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-11-13     Completed Date:  2007-02-23     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-7     Citation Subset:  IM    
Affiliation:
University of Cincinnati, Department of Psychiatry, Reading, OH 45237, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Fats / administration & dosage*
Hyperphagia / physiopathology*
Male
Rats
Rats, Long-Evans
Receptors, Dopamine / physiology*
Grant Support
ID/Acronym/Agency:
DK54080/DK/NIDDK NIH HHS; DK56863/DK/NIDDK NIH HHS; MH65353/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Receptors, Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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