| Role of dietary patterns for dioxin and PCB exposure. | |
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MedLine Citation:
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PMID: 19842105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary patterns were related to intake and blood concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs), dioxin-like polychlorinated biphenyls (dl-PCBs) and selected non-dioxin-like-PCBs (ndl-PCBs). Intake calculations were based on an extensive food frequency questionnaire and a congener-specific database on concentrations in Norwegian foods. The study (2003) applied a two-step inclusion strategy recruiting representative (n=73) and high consumers (n=111) of seafood and game. Estimated median intakes of sum PCDD/PCDFs and dl-PCBs of the representative and high consumers were 0.78 and 1.25 pg toxic equivalents (TEQ)/kg bw/day, respectively. Estimated median intakes of ndl-PCBs (sum chlorinated biphenyl (CB)-28, 52, 101, 138, 153, 180) were 4.26 and 6.40 ng/kg bw/day. The median blood concentrations of PCDD/PCDFs/dl-PCBs were 28.7 and 35.1 pg TEQ/g lipid, and ndl-PCBs (sum of CB-101, 138, 153 and 180) 252 and 299 ng/g lipid. The Spearman correlations between dietary intake and serum concentration were r=0.34 (p=0.017) for dl-compounds and r=0.37 (p<0.001) for ndl-PCBs. Oily fish was the major source of dl-compounds and ndl-PCBs in high and representative consumers. Four dietary patterns were identified by principal component analysis. Two were related to high intakes, one dominated by oily fish ((Omega-3)), the other by fish liver and seagull eggs ("northern coastal"). Only the latter was closely associated with high blood concentrations of dioxins and PCBs. |
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Authors:
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Helen E Kvalem; Helle K Knutsen; Cathrine Thomsen; Margaretha Haugen; Hein Stigum; Anne Lise Brantsaeter; May Fr??shaug; Nina Lohmann; Olaf P??pke; Georg Becher; Jan Alexander; Helle M Meltzer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 53 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 1438-51 Citation Subset: IM |
Affiliation:
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Norwegian Institute of Public Health, Oslo, Norway. helen.engelstad@fhi.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Benzofurans / administration & dosage, blood* Environmental Monitoring* Environmental Pollutants / blood* Female Food Habits* Humans Male Middle Aged Norway Polychlorinated Biphenyls / administration & dosage, blood* Polymers / administration & dosage Tetrachlorodibenzodioxin / administration & dosage, analogs & derivatives*, blood |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Environmental Pollutants; 0/Polychlorinated Biphenyls; 0/Polymers; 0/polychlorodibenzo-4-dioxin; 0/polychlorodibenzofuran; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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