Document Detail

Role of dietary patterns for dioxin and PCB exposure.
MedLine Citation:
PMID:  19842105     Owner:  NLM     Status:  MEDLINE    
Dietary patterns were related to intake and blood concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs), dioxin-like polychlorinated biphenyls (dl-PCBs) and selected non-dioxin-like-PCBs (ndl-PCBs). Intake calculations were based on an extensive food frequency questionnaire and a congener-specific database on concentrations in Norwegian foods. The study (2003) applied a two-step inclusion strategy recruiting representative (n=73) and high consumers (n=111) of seafood and game. Estimated median intakes of sum PCDD/PCDFs and dl-PCBs of the representative and high consumers were 0.78 and 1.25 pg toxic equivalents (TEQ)/kg bw/day, respectively. Estimated median intakes of ndl-PCBs (sum chlorinated biphenyl (CB)-28, 52, 101, 138, 153, 180) were 4.26 and 6.40 ng/kg bw/day. The median blood concentrations of PCDD/PCDFs/dl-PCBs were 28.7 and 35.1 pg TEQ/g lipid, and ndl-PCBs (sum of CB-101, 138, 153 and 180) 252 and 299 ng/g lipid. The Spearman correlations between dietary intake and serum concentration were r=0.34 (p=0.017) for dl-compounds and r=0.37 (p<0.001) for ndl-PCBs. Oily fish was the major source of dl-compounds and ndl-PCBs in high and representative consumers. Four dietary patterns were identified by principal component analysis. Two were related to high intakes, one dominated by oily fish ((Omega-3)), the other by fish liver and seagull eggs ("northern coastal"). Only the latter was closely associated with high blood concentrations of dioxins and PCBs.
Helen E Kvalem; Helle K Knutsen; Cathrine Thomsen; Margaretha Haugen; Hein Stigum; Anne Lise Brantsaeter; May Fr??shaug; Nina Lohmann; Olaf P??pke; Georg Becher; Jan Alexander; Helle M Meltzer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  53     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1438-51     Citation Subset:  IM    
Norwegian Institute of Public Health, Oslo, Norway.
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MeSH Terms
Aged, 80 and over
Benzofurans / administration & dosage,  blood*
Environmental Monitoring*
Environmental Pollutants / blood*
Food Habits*
Middle Aged
Polychlorinated Biphenyls / administration & dosage,  blood*
Polymers / administration & dosage
Tetrachlorodibenzodioxin / administration & dosage,  analogs & derivatives*,  blood
Reg. No./Substance:
0/Benzofurans; 0/Environmental Pollutants; 0/Polychlorinated Biphenyls; 0/Polymers; 0/polychlorodibenzo-4-dioxin; 0/polychlorodibenzofuran; 1746-01-6/Tetrachlorodibenzodioxin

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