| Role of diet in the development of inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 19462428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inflammatory bowel diseases (IBDs) are a group of heterogeneous disorders characterized by acute and chronic inflammatory changes in the small or large bowel, or in both. Increasing incidence and prevalence figures for IBD both in the developed and developing world indicate that environmental factors are at least as significant in IBD as genetic susceptibility. Of these, diet and the host microbiota are likely to play important but as yet poorly defined roles. The major constituents of a standard "Western" diet may contribute to, or protect against, intestinal inflammation via several mechanisms. These include the effects of insulin resistance and short-chain fatty acids such as butyrate, modification of intestinal permeability, the antiinflammatory role of polyunsaturated fatty acids, and the effect of sulfur compounds from protein on host microbiota. This detailed review critically assesses the evidence for the role of diet in the development of IBD and examines the evidence for obesity as a contributing factor to IBD pathogenesis. Particular attention is focused on methodological issues including suitability of cases and controls, confounders such as smoking, and total energy expenditure. |
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Authors:
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Christine A Chapman-Kiddell; Peter S W Davies; Lynda Gillen; Graham L Radford-Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Inflammatory bowel diseases Volume: 16 ISSN: 1536-4844 ISO Abbreviation: Inflamm. Bowel Dis. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-02 Revised Date: 2011-04-19 |
Medline Journal Info:
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Nlm Unique ID: 9508162 Medline TA: Inflamm Bowel Dis Country: United States |
Other Details:
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Languages: eng Pagination: 137-51 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Dietetics, Royal Brisbane and Women's Hospital, Queensland, Australia. Christine_Chapman-Kiddell@health.qld.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diet* Humans Inflammatory Bowel Diseases / etiology*, prevention & control Obesity / complications* |
| Comments/Corrections | |
Comment In:
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Inflamm Bowel Dis. 2011 Apr;17(4):1059
[PMID:
20722059
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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